Teaching target-oriented and diversity-oriented organic synthesis at Harvard University

被引：40

作者：

Burke, MD ^{[1
]}

Lalic, G ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

CHEMISTRY & BIOLOGY | 2002年 / 9卷 / 05期

关键词：

D O I：

10.1016/S1074-5521(02)00143-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diversity-oriented synthesis presents many formidable challenges to the practitioners of synthetic organic chemistry. Those challenges include the effective teaching of this new and evolving discipline to ensure that students are well positioned to begin exploring its full potential. Fortunately, the teaching of synthetic organic chemistry has a rich history in the context of target-oriented synthesis, and this precedent can serve as a strong foundation for meeting the challenges of teaching diversity-oriented synthesis.

引用

页码：535 / 541

页数：7

共 12 条

[1] CARLSON RG, 1974, ANNU REP MED CHEM, V9, P270
[2] Corey E. J., 1995, LOGIC CHEM SYNTHESIS
[3] COREY EJ, 1991, ANGEW CHEM INT EDIT, P445
[4] Tandem [4+2]/[3+2]cycloadditions of nitroalkenes .11. The synthesis of (+)-crotanecine
Denmark, SE
Thorarensen, A
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (01) : 125 - 137
[5] RECENT ADVANCES IN THE TOTAL SYNTHESIS OF STEROIDS VIA INTRAMOLECULAR CYCLOADDITION REACTIONS
KAMETANI, T
NEMOTO, H
[J]. TETRAHEDRON, 1981, 37 (01) : 3 - 16
[6] TOTAL SYNTHESIS OF THE L-HEXOSES
KO, SY
LEE, AWM
MASAMUNE, S
REED, LA
SHARPLESS, KB
WALKER, FJ
[J]. SCIENCE, 1983, 220 (4600) : 949 - 951
[7] A strategy for macrocyclic ring closure and functionalization aimed toward split-pool syntheses
Lee, D
Sello, JK
Schreiber, SL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (45) : 10648 - 10649
[8] Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis
Lee, DS
Sello, JK
Schreiber, SL
[J]. ORGANIC LETTERS, 2000, 2 (05) : 709 - 712
[9] Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product
Pelish, HE
Westwood, NJ
Feng, Y
Kirchhausen, T
Shair, MD
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (27) : 6740 - 6741
[10] Target-oriented and diversity-oriented organic synthesis in drug discovery
Schreiber, SL
[J]. SCIENCE, 2000, 287 (5460) : 1964 - 1969

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