Is there a future for cell-penetrating peptides in oligonucleotide delivery?

被引：62

作者：

Lee, Soo Hyeon ^{[1
]}

Castagner, Bastien ^{[1
]}

Leroux, Jean-Christophe ^{[1
]}

机构：

[1] Inst Pharmaceut Sci, Dept Chem & Appl Biosci, Zurich, Switzerland

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2013年 / 85卷 / 01期

关键词：

Oligonucleotide; siRNA; Cell-penetrating peptide; Endocytosis; Delivery; ARGININE-RICH PEPTIDES; IN-VIVO DELIVERY; SMALL INTERFERING RNA; SIRNA DELIVERY; MORPHOLINO OLIGOMER; MAMMALIAN-CELLS; PLASMA-MEMBRANE; GENE DELIVERY; NUCLEIC-ACID; ANTISENSE OLIGONUCLEOTIDES;

D O I：

10.1016/j.ejpb.2013.03.021

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cell-penetrating peptides have been widely investigated as delivery vehicles for oligonucleotides (e.g., siRNA and antisense oligonucleotides). Different delivery strategies can be used, such as co-incubation, direct conjugation, non-covalent complex, and modification on the surface of liposome or polymer complexes. However, several challenges remain for their preclinical and clinical development. Endosomal escape, lack of cell/tissue specificity, and toxicity are major concerns in the design of cell-penetrating peptide-mediated delivery systems. In this commentary, we highlight recent reports of cell-penetrating peptide incorporation into oligonucleotide delivery systems and underline the remaining challenges, particularly for preclinical and clinical applications. (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：5 / 11

页数：7

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