Gene, Cell and Antibody-Based Therapies for the Treatment of Age-Related Macular Degeneration

被引:21
作者
Akyol, Engin [1 ]
Lotery, Andrew [1 ]
机构
[1] Univ Southampton, Southampton Gen Hosp, Fac Med, Clin Neurosci Res Grp, Mailpoint 806,South Lab & Path Block,Tremona Rd, Southampton SO16 6YD, Hants, England
关键词
choroidal neovascularisation; geographic atrophy; gene therapy; macular degeneration; stem cell therapy; monoclonal antibodies; GEOGRAPHIC ATROPHY SECONDARY; ENDOTHELIAL GROWTH-FACTOR; FACTOR-H POLYMORPHISM; OPEN-LABEL; STEM-CELL; RANIBIZUMAB; PREVALENCE; TRIAL; INHIBITION; PHASE-1;
D O I
10.2147/BTT.S252581
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Here we discuss antibody, cell and gene-based therapies that are currently available and under investigation for both wet and dry age-related macular degeneration (AMD). We initially discuss ocular anatomy, AMD modelling as well as the underlying pathophysiology of AMD. The antibody-based trials which have revolutionised the management of wet AMD are reviewed. The latest concepts in antibody therapy for wet AMD such as the port delivery systems, bispecific antibodies, designed ankyrin repeat protein (DARPINs) and brolucizumab are explored. Furthermore, the antibody-based trials targeting the complement pathway to reduce progression of geographic atrophy (GA) in dry AMD are discussed. Stem cell therapy and gene therapy are novel treatment modalities with no established clinical use in wet or dry AMD. Here, we discuss their efficacy so far in clinical trials. Their benefits and risk in the treatment of both wet and dry AMD are evaluated.
引用
收藏
页码:83 / 94
页数:12
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