Advances in the use of mass spectral libraries for forensic toxicology

被引：19

作者：

Aebi, B ^{[1
]}

Bernhard, W ^{[1
]}

机构：

[1] Univ Bern, Inst Legal Med, CH-3012 Bern, Switzerland

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 2002年 / 26卷 / 03期

关键词：

D O I：

10.1093/jat/26.3.149

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Gas chromatography in combination with mass spectrometry (GC-MS) plays an important role in the field of analytical toxicology. The identification of unknown compounds is very frequently undertaken with GC-MS and utilizing mass spectral libraries. Currently available libraries for analytical toxicology were compared for overlapping and uniqueness of their entries. Furthermore, the widely known Pfleger-Maurer-Weber-Drugs-and-Pesticides-Library for toxicology (PMW_tox2) was used to compare the search algorithms PBM (Probability Based Matching, Agilent Technologies), INCOS (Finnigan/Thermoquest), and MassLib (Max Planck Institute). To our knowledge, direct comparisons of mass spectral libraries and search programs for analytical toxicology have not been published previously. The capabilities and necessities of modern MS technology in the field of general unknown analysis are revealed, and some of the potential pitfalls are described.

引用

页码：149 / 156

页数：8

共 14 条

[1] Gas chromatography with dual mass spectrometric and nitrogen-phosphorus specific detection: a new and powerful tool for forensic analyses [J].