Flexible endoscope for continuous in vivo multispectral fluorescence lifetime imaging

被引：26

作者：

Cheng, Shuna ^{[1
]}

Rico-Jimenez, J. Jesus ^{[1
]}

Jabbour, Joey ^{[1
]}

Malik, Bilal ^{[1
]}

Maitland, Kristen C. ^{[1
]}

Wright, John ^{[2
]}

Cheng, Yi-Shing Lisa ^{[2
]}

Jo, Javier A. ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA

[2] Texas A&M Univ, Hlth Sci Ctr, Baylor Coll Dent, Dept Diagnost Sci, Dallas, TX 75246 USA

来源：

OPTICS LETTERS | 2013年 / 38卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Fluorescence imaging - Tissue;

D O I：

10.1364/OL.38.001515

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Fluorescence lifetime imaging (FLIM) offers a noninvasive approach for characterizing the biochemical composition of biological tissue. There has been an increasing interest in the application of multispectral FLIM for medical diagnosis. Central to the clinical translation of FLIM technology is the development of compact and high-speed endoscopy systems. Unfortunately, the predominant multispectral FLIM approaches suffer from limitations that impede the development of endoscopy systems that are suitable for in vivo tissue imaging. We present a compact wide-field time-gated FLIM flexible endoscope capable of continuous lifetime imaging of up to three fluorescence emission bands simultaneously. This endoscope design will facilitate the evaluation of FLIM for in vivo applications. (C) 2013 Optical Society of America

引用

页码：1515 / 1517

页数：3

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