Cumulative exposure to environmental pollutants during early pregnancy and reduced fetal growth: the Project Viva cohort

被引:32
作者
Rokoff, Lisa B. [1 ]
Rifas-Shiman, Sheryl L. [1 ]
Coull, Brent A. [2 ]
Cardenas, Andres [1 ]
Calafat, Antonia M. [3 ]
Ye, Xiaoyun [3 ]
Gryparis, Alexandros [4 ]
Schwartz, Joel [5 ]
Sagiv, Sharon K. [6 ,7 ]
Gold, Diane R.
Oken, Emily [8 ]
Fleisch, Abby F. [9 ,10 ]
机构
[1] Harvard Med Sch & Harvard Pilgrim Hlth Care Inst, Div Chron Dis Res Lifecourse, Dept Populat Med, 401 Pk Dr,Suite 401, Boston, MA 02215 USA
[2] Harvard T H Chan Sch Publ Hlth, Dept Biostatist, Boston, MA USA
[3] Div Sci Lab, Natl Ctr Environm Hlth, Centers Dis Control & Prevent, Atlanta, GA USA
[4] Univ Athens Med Sch, Dept Hyg, Epidemiol & Med Stat, Athens, Greece
[5] Harvard T H Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA
[6] Univ Calif Berkeley, Ctr Environm Res & Childrens Hlth, Berkeley, CA USA
[7] Berkeley Sch Publ Hlth, Univ Calif, Div Epidemiol, Berkeley, CA USA
[8] Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA
[9] Maine Med Ctr, Pediatr Endocrinol & Diabet, Portland, ME USA
[10] Maine Med Ctr Res Inst, Ctr Outcomes Res & Evaluat, Portland, ME USA
来源
ENVIRONMENTAL HEALTH | 2018年 / 17卷
基金
美国国家卫生研究院;
关键词
Pregnancy; Birth weight; Epidemiology; Air pollution; Smoking; Perfluoroalkyl substances; ACTIVATED-RECEPTOR-ALPHA; BIRTH-WEIGHT; PARTICULATE MATTER; AIR-POLLUTION; PERFLUOROALKYL ACIDS; STOPPING SMOKING; BLACK CARBON; HEALTH; ASSOCIATIONS; OUTCOMES;
D O I
10.1186/s12940-018-0363-4
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Reduced fetal growth is associated with perinatal and later morbidity. Prenatal exposure to environmental pollutants is linked to reduced fetal growth at birth, but the impact of concomitant exposure to multiple pollutants is unclear. The purpose of this study was to examine interactions between early pregnancy exposure to cigarette smoke, traffic pollution, and select perfluoroalkyl substances (PFASs) on birth weight-for-gestational age (BW/GA). Methods: Among 1597 Project Viva mother-infant pairs, we assessed maternal cigarette smoking by questionnaire, traffic pollution at residential address by black carbon land use regression model, and plasma concentration of select PFASs in early pregnancy. We calculated sex-specific BW/GA z-scores, an index of fetal growth, from national reference data. We fit covariate-adjusted multi-pollutant linear regression models and examined interactions between exposures, using a likelihood-ratio test to identify a best-fit model. Results: Two hundred six (13%) mothers smoked during pregnancy. Mean [standard deviation (SD)] for black carbon was 0.8 (0.3) mu g/m(3), perfluorooctane sulfonate (PFOS) was 29.1 (16.5) ng/mL, and BW/GA z-score was 0.19 (0.96). In the best-fit model, BW/GA z-score was lower in infants of mothers exposed to greater black carbon [-0.08 (95% CI: -0.15, -0.01) per interquartile range (IQR)]. BW/GA z-score (95% CI) was also lower in infants of mothers who smoked [-0.09 (-0.23, 0.06)] or were exposed to greater PFOS [-0.03 (-0.07, 0.02) per IQR], although confidence intervals crossed the null. There were no interactions between exposures. In secondary analyses, instead of PFOS, we examined perfluorononanoate (PFNA) [mean (SD): 0.7 (0.4) ng/mL], a PFAS more closely linked to lower BW/GA in our cohort. The best-fit multi-pollutant model included positive two-way interactions between PFNA and both black carbon and smoking (p-interactions = 0.03). Conclusions: Concurrent prenatal exposures to maternal smoking, black carbon, and PFOS are additively associated with lower fetal growth, whereas PFNA may attenuate associations of smoking and black carbon with lower fetal growth. It is important to examine interactions between multiple exposures in relation to health outcomes, as effects may not always be additive and may shed light on biological pathways.
引用
收藏
页数:11
相关论文
共 52 条
[1]   Review of the expression of peroxisome proliferator-activated receptors alpha (PPARα), beta (PPARβ), and gamma (PPARγ) in rodent and human development [J].
Abbott, Barbara D. .
REPRODUCTIVE TOXICOLOGY, 2009, 27 (3-4) :246-257
[2]   Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review [J].
Bach, Cathrine Carlsen ;
Bech, Bodil Hammer ;
Brix, Nis ;
Nohr, Ellen Aagaard ;
Bonde, Jens Peter Ellekilde ;
Henriksen, Tine Brink .
CRITICAL REVIEWS IN TOXICOLOGY, 2015, 45 (01) :53-67
[3]   Adult consequences of fetal growth restriction [J].
Barker, David J. P. .
CLINICAL OBSTETRICS AND GYNECOLOGY, 2006, 49 (02) :270-283
[4]   Serum concentrations of 11 polyfluoroalkyl compounds in the US population: Data from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 [J].
Calafat, Antonia M. ;
Kuklenyik, Zsuzsanna ;
Reidy, John A. ;
Caudill, Samuel P. ;
Tully, Jason S. ;
Needham, Larry L. .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2007, 41 (07) :2237-2242
[5]  
Centers for Disease Control and Prevention, 2017, UPD TABL, VOne
[6]   Illustrating bias due to conditioning on a collider [J].
Cole, Stephen R. ;
Platt, Robert W. ;
Schisterman, Enrique F. ;
Chu, Haitao ;
Westreich, Daniel ;
Richardson, David ;
Poole, Charles .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2010, 39 (02) :417-420
[7]   Air pollution and infant health: Lessons from New Jersey [J].
Currie, Janet ;
Neidell, Matthew ;
Schmieder, Johannes F. .
JOURNAL OF HEALTH ECONOMICS, 2009, 28 (03) :688-703
[8]  
DeWitt J, 2009, CRIT REV TOXICOL, V39, P76, DOI [10.1080/10408440802209804, 10.1080/10408440802209804 ]
[9]   Protecting Human Health From Air Pollution Shifting From a Single-pollutant to a Multipollutant Approach [J].
Dominici, Francesca ;
Peng, Roger D. ;
Barr, Christopher D. ;
Bell, Michelle L. .
EPIDEMIOLOGY, 2010, 21 (02) :187-194
[10]   Air pollution, neighbourhood and maternal-level factors modify the effect of smoking on birth weight: a multilevel analysis in British Columbia, Canada [J].
Erickson, Anders C. ;
Ostry, Aleck ;
Chan, Hing Man ;
Arbour, Laura .
BMC PUBLIC HEALTH, 2016, 16 :1-12