The emerging role of exosomes in mental disorders

被引：306

作者：

Saeedi, Saumeh ^{[1
,2
]}

Israel, Sonia ^{[1
]}

Nagy, Corina ^{[1
]}

Turecki, Gustavo ^{[1
,3
]}

机构：

[1] McGill Univ, Douglas Mental Hlth Univ Inst, McGill Grp Suicide Studies, Montreal, PQ, Canada

[2] McGill Univ, Dept Human Genet, Montreal, PQ, Canada

[3] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

来源：

TRANSLATIONAL PSYCHIATRY | 2019年 / 9卷 / 1期

关键词：

BLOOD-BRAIN-BARRIER; ASTROCYTE-DERIVED EXOSOMES; MAJOR DEPRESSIVE DISORDER; EXTRACELLULAR VESICLES; SYNAPTIC PLASTICITY; NEURONAL EXOSOMES; NERVOUS-SYSTEM; SEROTONIN; STRESS; MICRORNA;

D O I：

10.1038/s41398-019-0459-9

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Exosomes are a class of extracellular vesicles of endocytic origin, which are released by cells and are accessible in biofluids, such as saliva, urine, and plasma. These vesicles are enriched with small RNA, and they play a role in many physiological processes. In the brain, they are involved in processes including synaptic plasticity, neuronal stress response, cell-to-cell communication and neurogenesis. While exosomes have been implicated previously in cancer and neurodegenerative diseases, research regarding their role in mental disorders remains scarce. Given their functional significance in the brain, investigation in this field is warranted. Additionally, because exosomes can cross the blood-brain barrier, they may serve as accessible biomarkers of neural dysfunction. Studying exosomes may provide information towards diagnosis and therapeutic intervention, and specifically those derived from the brain may provide a mechanistic view of the disease phenotype. This review will discuss the roles of exosomes in the brain, and relate novel findings to current insights into mental disorders.

引用

页数：11

共 100 条

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