A simple model for quantification of the radiobiological effectiveness of the 10B(n,α)7Li capture reaction in BNCT

被引：4
作者：
Hsieh, CH
Liu, HM
Hwang, JJ
Wang, HE
Kai, JJ
Chen, FD
机构：
[1] Natl Yang Ming Univ, Dept Med Radiat Technol, Taipei 112, Taiwan
[2] Natl Yang Ming Univ, Inst Radiol Sci, Taipei 112, Taiwan
[3] Natl Tsing Hua Univ, Nucl Sci & Technol Dev Ctr, Hsinchu, Taiwan
[4] Natl Tsing Hua Univ, Dept Engn & Syst Sci, Hsinchu, Taiwan
[5] Chungtai Inst Hlth Sci & Technol, Inst Radiol Sci, Taichung, Taiwan
来源：
APPLIED RADIATION AND ISOTOPES | 2006年 / 64卷 / 03期
关键词：
boron neutron capture therapy (BNCT); F98; glioma; BPA-Fr;
D O I：
10.1016/j.apradiso.2005.08.018
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A simple model has been developed for predicting radiobiological effectiveness of the neutron capture reaction in boron neutron capture therapy. This model was derived from the relationship between the cell survival from the boron capture reaction, the intracellular boron concentration, and the thermal neutron fluence. We found that the cell-killing effect of the boron capture reaction was well described using a power function of the intracellular boron concentration. Hence the relationship between cell survival from the boron capture reaction, intracellular boron concentration, and the thermal neutron fluence could be determined using a simple mathematical equation. We consider that our current approach is more appropriate and realistic than the conventional theoretical mathematical model used to estimate the radiobiological effectiveness of the neutron capture reaction in boron neutron capture therapy. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：306 / 314
页数：9
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