Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS

被引：61

作者：

Brunel, Anne-Sophie ^{[1
]}

Reynes, Jacques ^{[1
,2
]}

Tuaillon, Edouard ^{[3
,4
,5
]}

Rubbo, Pierre-Alain ^{[3
,4
]}

Lortholary, Olivier ^{[5
,6
,7
]}

Montes, Brigitte

Le Moing, Vincent ^{[1
,2
]}

Makinson, Alain ^{[1
,2
]}

机构：

[1] Montpellier Univ Hosp, Dept Infect Dis, F-34295 Montpellier, France

[2] Univ Montpellier I, TransVIHMI, IRD, UMI 233, Montpellier, France

[3] INSERM, U1058, Montpellier, France

[4] Montpellier Univ Hosp, Inst Res Biotherapy, F-34295 Montpellier, France

[5] Montpellier Univ Hosp, Virol Lab, F-34295 Montpellier, France

[6] Univ Paris 05, Necker Enfants Malad Hosp, Infect & Trop Dis Dept, Paris, France

[7] Inst Pasteur, CNRS, Mol Mycol Unit, CNRMA,URA 3012, Paris, France

来源：

AIDS | 2012年 / 26卷 / 16期

关键词：

D O I：

10.1097/QAD.0b013e328358daea

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Management of relapsing or refractory immune reconstitution inflammatory syndromes (IRISs) despite corticosteroid therapy is yet to be defined. We describe three HIV-infected patients with corticosteroid-dependent and life-threatening paradoxical immune reconstitution inflammatory syndrome for whom thalidomide treatment induced rapid clinical remission and permitted complete corticosteroid withdrawal without clinical relapse.

引用

页码：2110 / 2112

页数：3

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