Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS

被引：61

作者：

Brunel, Anne-Sophie ^{[1
]}

Reynes, Jacques ^{[1
,2
]}

Tuaillon, Edouard ^{[3
,4
,5
]}

Rubbo, Pierre-Alain ^{[3
,4
]}

Lortholary, Olivier ^{[5
,6
,7
]}

Montes, Brigitte

Le Moing, Vincent ^{[1
,2
]}

Makinson, Alain ^{[1
,2
]}

机构：

[1] Montpellier Univ Hosp, Dept Infect Dis, F-34295 Montpellier, France

[2] Univ Montpellier I, TransVIHMI, IRD, UMI 233, Montpellier, France

[3] INSERM, U1058, Montpellier, France

[4] Montpellier Univ Hosp, Inst Res Biotherapy, F-34295 Montpellier, France

[5] Montpellier Univ Hosp, Virol Lab, F-34295 Montpellier, France

[6] Univ Paris 05, Necker Enfants Malad Hosp, Infect & Trop Dis Dept, Paris, France

[7] Inst Pasteur, CNRS, Mol Mycol Unit, CNRMA,URA 3012, Paris, France

来源：

AIDS | 2012年 / 26卷 / 16期

关键词：

D O I：

10.1097/QAD.0b013e328358daea

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Management of relapsing or refractory immune reconstitution inflammatory syndromes (IRISs) despite corticosteroid therapy is yet to be defined. We describe three HIV-infected patients with corticosteroid-dependent and life-threatening paradoxical immune reconstitution inflammatory syndrome for whom thalidomide treatment induced rapid clinical remission and permitted complete corticosteroid withdrawal without clinical relapse.

引用

页码：2110 / 2112

页数：3

共 13 条

[1] Therapeutic Use of Infliximab in Tuberculosis to Control Severe Paradoxical Reaction of the Brain and Lymph Nodes [J].

Blackmore, Timothy K. ;

Manning, Laurens ;

Taylor, William J. ;

Wallis, Robert S. .

CLINICAL INFECTIOUS DISEASES, 2008, 47 (10) :E83-E85

[2] Immunopathogenesis and Diagnosis of Tuberculosis and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome during Early Antiretroviral Therapy [J].

Elliott, Julian H. ;

Vohith, Khol ;

Saramony, Sarun ;

Savuth, Chin ;

Dara, Chan ;

Sarim, Chel ;

Huffam, Sarah ;

Oelrichs, Robert ;

Sophea, Pouv ;

Saphonn, Vonthanak ;

Kaldor, John ;

Cooper, David A. ;

Vun, Mean Chhi ;

French, Martyn A. .

JOURNAL OF INFECTIOUS DISEASES, 2009, 200 (11) :1736-1745

[3] Cryptococcal immune reconstitution inflammatory syndrome in HIV-1-infected individuals: proposed clinical case definitions [J].

Haddow, Lewis J. ;

Colebunders, Robert ;

Meintjes, Graeme ;

Lawn, Stephen D. ;

Elliott, Julian H. ;

Manabe, Yukari C. ;

Bohjanen, Paul R. ;

Sungkanuparph, Somnuek ;

Easterbrook, Philippa J. ;

French, Martyn A. ;

Boulware, David R. .

LANCET INFECTIOUS DISEASES, 2010, 10 (11) :791-802

[4] Thalidomide for the treatment of oral aphthous ulcers in patients with human immunodeficiency virus infection [J].

Jacobson, JM ;

Greenspan, JS ;

Spritzler, J ;

Ketter, N ;

Fahey, JL ;

Jackson, JB ;

Fox, L ;

Chernoff, M ;

Wu, AW ;

MacPhail, LA ;

Vasquez, GJ ;

Wohl, DA .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (21) :1487-1493

[5] Activity of thalidomide in AIDS-related Kaposis's sarcoma [J].

Little, RF ;

Wyvill, KM ;

Pluda, JM ;

Welles, L ;

Marshall, V ;

Figg, WD ;

Newcomb, FM ;

Tosato, G ;

Feigal, E ;

Steinberg, SM ;

Whitby, D ;

Goedert, JJ ;

Yarchoan, R .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (13) :2593-2602

[6] Incidence and risk factors of immune reconstitution inflammatory syndrome complicating HIV-associated cryptococcosis in France [J].

Lortholary, O ;

Fontanet, A ;

Mémain, N ;

Martin, A ;

Sitbon, K ;

Dromer, F .

AIDS, 2005, 19 (10) :1043-1049

[7] Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome [J].

Meintjes, Graeme ;

Wilkinson, Robert J. ;

Morroni, Chelsea ;

Pepper, Dominique J. ;

Rebe, Kevin ;

Rangaka, Molebogeng X. ;

Oni, Tolu ;

Maartens, Gary .

AIDS, 2010, 24 (15) :2381-2390

[8] Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America [J].

Perfect, John R. ;

Dismukes, William E. ;

Dromer, Francoise ;

Goldman, David L. ;

Graybill, John R. ;

Hamill, Richard J. ;

Harrison, Thomas S. ;

Larsen, Robert A. ;

Lortholary, Olivier ;

Nguyen, Minh-Hong ;

Pappas, Peter G. ;

Powderly, William G. ;

Singh, Nina ;

Sobel, Jack D. ;

Sorrell, Tania C. .

CLINICAL INFECTIOUS DISEASES, 2010, 50 (03) :291-322

[9] THALIDOMIDE INHIBITS TUMOR-NECROSIS-FACTOR-ALPHA PRODUCTION BY LIPOPOLYSACCHARIDE-STIMULATED AND LIPOARABINOMANNAN-STIMULATED HUMAN MICROGLIAL CELLS [J].

PETERSON, PK ;

HU, SX ;

SHENG, WS ;

KRAVITZ, FH ;

MOLITOR, TW ;

CHATTERJEE, D ;

CHAO, CC .

JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (04) :1137-1140

[10] Adjunctive thalidomide therapy for childhood tuberculous meningitis: Results of a randomized study [J].

Schoeman, JF ;

Springer, P ;

van Rensburg, AJ ;

Swanevelder, S ;

Hanekom, WA ;

Haslett, PAJ ;

Kaplan, G .

JOURNAL OF CHILD NEUROLOGY, 2004, 19 (04) :250-257

← 1 2 →