Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus

被引：379
作者：
Palomer, Xavier [1 ,2 ]
Pizarro-Delgado, Javier [1 ,2 ]
Barroso, Emma [1 ,2 ]
Vazquez-Carrera, Manuel [1 ,2 ]
机构：
[1] Univ Barcelona, Dept Pharmacol Toxicol & Therapeut Chem, Fac Pharm & Food Sci, IBUB,Pediat Res Inst,Hosp St Joan de Deu, Avinguda Joan 23 27-31, E-08028 Barcelona, Spain
[2] Inst Salud Carlos III, Spanish Biomed Res Ctr Diabet & Associated Metab, Avinguda Joan 23 27-31, E-08028 Barcelona, Spain
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 03期
关键词：
SKELETAL-MUSCLE CELLS; ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; TRIBBLES HOMOLOG; BETA-CELLS; ER STRESS; OLEATE; ACTIVATION; APOPTOSIS; AMPK;
D O I：
10.1016/j.tem.2017.11.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic acid, the monounsaturated FA (MUFA) oleic acid elicits beneficial effects on insulin sensitivity, and the dietary palmitic acid: oleic acid ratio impacts diabetes risk in humans. Here we review recent mechanistic insights into the beneficial effects of oleic acid compared with palmitic acid on insulin resistance and T2DM, including its anti-inflammatory actions, and its capacity to inhibit endoplasmic reticulum (ER) stress, prevent attenuation of the insulin signaling pathway, and improve b cell survival. Understanding the molecular mechanisms of the antidiabetic effects of oleic acid may contribute to understanding the benefits of this FA in the prevention or delay of T2DM.
引用
收藏
页码：178 / 190
页数：13
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