Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus

被引：379
作者：
Palomer, Xavier [1 ,2 ]
Pizarro-Delgado, Javier [1 ,2 ]
Barroso, Emma [1 ,2 ]
Vazquez-Carrera, Manuel [1 ,2 ]
机构：
[1] Univ Barcelona, Dept Pharmacol Toxicol & Therapeut Chem, Fac Pharm & Food Sci, IBUB,Pediat Res Inst,Hosp St Joan de Deu, Avinguda Joan 23 27-31, E-08028 Barcelona, Spain
[2] Inst Salud Carlos III, Spanish Biomed Res Ctr Diabet & Associated Metab, Avinguda Joan 23 27-31, E-08028 Barcelona, Spain
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 03期
关键词：
SKELETAL-MUSCLE CELLS; ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; TRIBBLES HOMOLOG; BETA-CELLS; ER STRESS; OLEATE; ACTIVATION; APOPTOSIS; AMPK;
D O I：
10.1016/j.tem.2017.11.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic acid, the monounsaturated FA (MUFA) oleic acid elicits beneficial effects on insulin sensitivity, and the dietary palmitic acid: oleic acid ratio impacts diabetes risk in humans. Here we review recent mechanistic insights into the beneficial effects of oleic acid compared with palmitic acid on insulin resistance and T2DM, including its anti-inflammatory actions, and its capacity to inhibit endoplasmic reticulum (ER) stress, prevent attenuation of the insulin signaling pathway, and improve b cell survival. Understanding the molecular mechanisms of the antidiabetic effects of oleic acid may contribute to understanding the benefits of this FA in the prevention or delay of T2DM.
引用
收藏
页码：178 / 190
页数：13
相关论文
共 73 条
  • [21] Increased Mitochondrial Fatty Acid Oxidation Is Sufficient to Protect Skeletal Muscle Cells from Palmitate-induced Apoptosis
    Henique, Carole
    Mansouri, Abdelhak
    Fumey, Gwladys
    Lenoir, Veronique
    Girard, Jean
    Bouillaud, Frederic
    Prip-Buus, Carina
    Cohen, Isabelle
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (47) : 36818 - 36827
  • [22] Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
    Holland, William L.
    Miller, Russell A.
    Wang, Zhao V.
    Sun, Kai
    Barth, Brian M.
    Bui, Hai H.
    Davis, Kathryn E.
    Bikman, Benjamin T.
    Halberg, Nils
    Rutkowski, Joseph M.
    Wade, Mark R.
    Tenorio, Vincent M.
    Kuo, Ming-Shang
    Brozinick, Joseph T.
    Zhang, Bei B.
    Birnbaum, Morris J.
    Summers, Scott A.
    Scherer, Philipp E.
    [J]. NATURE MEDICINE, 2011, 17 (01) : 55 - U226
  • [23] Differential Regulation of Dihydroceramide Desaturase by Palmitate versus Monounsaturated Fatty Acids IMPLICATIONS FOR INSULIN RESISTANCE
    Hu, Wei
    Ross, Jessica
    Geng, Tuoyu
    Brice, Sarah E.
    Cowart, L. Ashley
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (19) : 16596 - 16605
  • [24] Essential Role for Protein Kinase Cζ in Oleic Acid-Induced Glucagon-Like Peptide-1 Secretion in Vivo in the Rat
    Iakoubov, Roman
    Ahmed, Ausma
    Lauffer, Lina M.
    Bazinet, Richard P.
    Brubaker, Patricia L.
    [J]. ENDOCRINOLOGY, 2011, 152 (04) : 1244 - 1252
  • [25] Associations of Fatty Acids in Cerebrospinal Fluid with Peripheral Glucose Concentrations and Energy Metabolism
    Jumpertz, Reiner
    Guijarro, Ana
    Pratley, Richard E.
    Mason, Clinton C.
    Piomelli, Daniele
    Krakoff, Jonathan
    [J]. PLOS ONE, 2012, 7 (07):
  • [26] A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults
    Kien, C. Lawrence
    Bunn, Janice Y.
    Poynter, Matthew E.
    Stevens, Robert
    Bain, James
    Ikayeva, Olga
    Fukagawa, Naomi K.
    Champagne, Catherine M.
    Crain, Karen I.
    Koves, Timothy R.
    Muoio, Deborah M.
    [J]. DIABETES, 2013, 62 (04) : 1054 - 1063
  • [27] Inhibition of fatty acid translocase cluster determinant 36 (CD36), stimulated by hyperglycemia, prevents glucotoxicity in INS-1 cells
    Kim, Yong-Woon
    Moon, Jun Sung
    Seo, Ye Jin
    Park, So-Young
    Kim, Jong-Yeon
    Yoon, Ji Sung
    Lee, In-Kyu
    Lee, Hyoung Woo
    Won, Kyu Chang
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 420 (02) : 462 - 466
  • [28] Kopel E, 2014, ANN INTERN MED, V161, P157, DOI [10.7326/M13-1725, 10.7326/L14-5014, 10.7326/L14-5014-2]
  • [29] Macrophage polarization in obesity and type 2 diabetes: weighing down our understanding of macrophage function?
    Kraakman, Michael James
    Murphy, Andrew James
    Jandeleit-Dahm, Karin
    Kammoun, Helene L.
    [J]. FRONTIERS IN IMMUNOLOGY, 2014, 5
  • [30] Free fatty acid receptor 1 (FFAR1/GPR40) signaling affects insulin secretion by enhancing mitochondrial respiration during palmitate exposure
    Kristinsson, Hjalti
    Bergsten, Peter
    Sargsyan, Ernest
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2015, 1853 (12): : 3248 - 3257
12345678