Synthesis of novel trifluoromethyl-containing heterocycle-fused troponoid compounds

被引：1

作者：

Gao, Wentao ^{[1
]}

Liu, Rui ^{[1
]}

Li, Yang ^{[1
]}

机构：

[1] Bohai Univ, Inst Superfine Chem, Jinzhou 121000, Peoples R China

来源：

HETEROCYCLIC COMMUNICATIONS | 2012年 / 18卷 / 04期

关键词：

aromatic hydrazine; Claisen-Schmidt condensation; cyclization; hydroxylamine hydrochloride; trifluoromethyl; tropone; I-2/DMSO/H2SO4; SYSTEM; BIOLOGICAL EVALUATION; ACID-DERIVATIVES; TROPOLONE; ARYLAZO; 3-CINNAMOYLTROPOLONES; CYCLIZATION; INHIBITORS; POTENT; BROMO;

D O I：

10.1515/hc-2012-0122

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile synthesis of novel trifluoromethyl-containing pyrano-, pyrazolo- and isoxazolo-fused tropone compounds 4a,b, 5a,b, and 6a,b, respectively, by cyclizations of (E)-3-[3-(trifluoromethylphenyl)acryloyl] tropolones 3a,b is described. The substrates 3a, b were prepared by Claisen-Schmidt condensation reaction of 3-acetyltropolone (1) with 3- or 4-(trifluoromethyl)benzaldehydes 2a,b.

引用

页码：223 / 226

页数：4

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