Synthesis of novel trifluoromethyl-containing heterocycle-fused troponoid compounds

被引：1
|
作者：
Gao, Wentao [1 ]
Liu, Rui [1 ]
Li, Yang [1 ]
机构：
[1] Bohai Univ, Inst Superfine Chem, Jinzhou 121000, Peoples R China
来源：
HETEROCYCLIC COMMUNICATIONS | 2012年 / 18卷 / 04期
关键词：
aromatic hydrazine; Claisen-Schmidt condensation; cyclization; hydroxylamine hydrochloride; trifluoromethyl; tropone; I-2/DMSO/H2SO4; SYSTEM; BIOLOGICAL EVALUATION; ACID-DERIVATIVES; TROPOLONE; ARYLAZO; 3-CINNAMOYLTROPOLONES; CYCLIZATION; INHIBITORS; POTENT; BROMO;
D O I：
10.1515/hc-2012-0122
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile synthesis of novel trifluoromethyl-containing pyrano-, pyrazolo- and isoxazolo-fused tropone compounds 4a,b, 5a,b, and 6a,b, respectively, by cyclizations of (E)-3-[3-(trifluoromethylphenyl)acryloyl] tropolones 3a,b is described. The substrates 3a, b were prepared by Claisen-Schmidt condensation reaction of 3-acetyltropolone (1) with 3- or 4-(trifluoromethyl)benzaldehydes 2a,b.
引用
收藏
页码：223 / 226
页数：4
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