Multitargeted therapy of cancer by silymarin

被引：337

作者：

Ramasamy, Kumaraguruparan ^{[1
]}

Agarwal, Rajesh ^{[1
,2
]}

机构：

[1] Univ Colorado, Dept Pharmaceut Sci, Sch Pharm, Denver, CO 80262 USA

[2] Univ Colorado, Ctr Canc, Denver, CO 80262 USA

来源：

CANCER LETTERS | 2008年 / 269卷 / 02期

关键词：

Silymarin; Silibinin; Chemoprevention; Carcinogenesis; Cell cycle; Cancer;

D O I：

10.1016/j.canlet.2008.03.053

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Silymarin, a flavonolignan from milk thistle (Siybum marianum) plant, is used for the protection against various liver conditions in both clinical settings and experimental models. In this review, we summarize the recent investigations and mechanistic studies regarding possible molecular targets of silymarin for cancer prevention. Number of studies has established the cancer chemopreventive role of silymarin in both in vivo and in vitro models. Silymarin modulates imbalance between cell survival and apoptosis through interference with the expressions of cell cycle regulators and proteins involved in apoptosis. In addition, silymarin also showed anti-inflammatory as well as anti-metastatic activity. Further, the protective effects of silymarin and its major active constituent, silibinin, studied in various tissues, suggest a clinical application in cancer patients as an adjunct to established therapies, to prevent or reduce chemotherapy as well as radiotherapy-induced toxicity. This review focuses on the chemistry and analogues of silymarin, multiple possible molecular mechanisms, in vitro as well as in vivo anti-cancer activities, and studies on human clinical trials. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：352 / 362

页数：11

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