Patterns of Initial Disease Recurrence after Resection of Biliary Tract Cancer

被引：44

作者：

Jung, Se Jin ^{[1
]}

Woo, Sang Myung ^{[1
]}

Park, Hyung Ki ^{[1
]}

Lee, Woo Jin ^{[1
]}

Han, Mi Ah ^{[2
,3
]}

Han, Sung-Sik ^{[1
]}

Kim, Seong Hoon ^{[1
]}

Park, Sang-Jae ^{[1
]}

Kim, Tae Hyun ^{[1
]}

Koh, Young Hwan ^{[1
]}

Hong, Eun Kyung ^{[1
]}

机构：

[1] Natl Canc Ctr, Ctr Liver Canc, Goyang, South Korea

[2] Natl Canc Ctr, Natl Canc Control Inst, Goyang Si 410769, Gyeonggi Do, South Korea

[3] Chosun Univ, Coll Med, Dept Prevent Med, Kwangju, South Korea

来源：

ONCOLOGY | 2012年 / 83卷 / 02期

关键词：

Adjuvant therapy; Biliary tract cancer; Recurrence; LYMPH-NODE ASSESSMENT; INTRAHEPATIC CHOLANGIOCARCINOMA; BILE-DUCT; POSTOPERATIVE RADIOTHERAPY; HILAR CHOLANGIOCARCINOMA; GALLBLADDER CARCINOMA; ADJUVANT; SURVIVAL; ADENOCARCINOMA; CHEMORADIATION;

D O I：

10.1159/000339695

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives:This study aimed to provide further insights into the indications for adjuvant therapeutic strategies via analysis of the sites of initial recurrence after resection of gallbladder cancer (GBC) and intrahepatic (IHC) and extrahepatic cholangiocarcinoma (EHC). Methods: Patients with biliary tract cancer who underwent potentially curative resection were identified from the database. Sites of initial disease recurrence were categorized as locoregional or distant. Results: Between March 2001 and April 2009, 231 patients underwent curative resection. Initial GBC and IHC recurrence involving a distant site occurred in 70.8 and 86.8% patients, respectively, compared to 56.9% patients with EHC (p = 0.002). The median time to disease recurrence (TTR) was shorter among the GBC and IHC groups compared with that in EHC patients (6.3 and 6.7 vs. 13.1 months, respectively; p = 0.003). Moreover, median times to distant recurrence in GBC and IHC groups were shorter than that in EHC (5.8 and 6.5 vs. 14.1 months, respectively; p = 0.002). Conclusions: After resection, recurrent GBC and IHC are more likely to involve a distant site and are associated with significantly shorter TTR than recurrent EHC. These findings suggest that an adjuvant therapeutic strategy targeting distant disease is likely to have a significant impact on the overall management of GBC and IHC. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：83 / 90

页数：8

共 31 条

[11] Patterns of initial disease recurrence after resection of gallbladder carcinoma and hilar cholangiocarcinoma - Implications for adjuvant therapeutic strategies [J].