Chemistry of phosphorus ylides 32: synthesis of phosphoranylidene-pyrano- and -cyclobutyl-xanthenones with potential antitumor activity

被引：6

作者：

Soliman, Fouad M. ^{[1
]}

Said, Medhat M. ^{[1
]}

Youns, Mahmoud ^{[2
]}

Darwish, Shaban A. ^{[1
]}

机构：

[1] Natl Res Ctr, Dept Organometall & Organometalloid Chem, Cairo, Egypt

[2] Helwan Univ, Fac Pharm, Dept Biochem & Mol Biol, Cairo, Egypt

来源：

MONATSHEFTE FUR CHEMIE | 2012年 / 143卷 / 06期

关键词：

Active phosphacumulenes; Xanthenones; Cyclobutanes; Pyranoxanthenones; Antitumor activity; PROTEIN-KINASE-C; ANTIOXIDANT XANTHONES; DERIVATIVES; INHIBITORS; ROUTE;

D O I：

10.1007/s00706-011-0683-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of active phosphacumulenes with xanthenones and anthrone yields xanthene(anthracene)- and/or phosphoranylidene xanthene(anthracene)- depending upon the nature of reactants and reaction conditions. Pertinent reaction mechanisms were considered and compatible spectroscopic measurements were recorded for all new compounds. The cytotoxic activity of some new products was evaluated against human cervical and breast carcinoma cell lines. Certain tested compounds showed promising results.

引用

页码：965 / 973

页数：9

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