Reagents for labeling with pH-independent fluorescein-based tags

被引：1
|
作者：
Zelinskiy, Stanislav N. [1 ]
Danilovtseva, Elena N. [1 ]
Pal'shin, Viktor A. [1 ]
Krishnan, Uma M. [2 ]
Annenkov, Vadim V. [1 ]
机构：
[1] Russian Acad Sci, Siberian Branch, Limnol Inst, 3 Ulan Batorskaya St,POB 278, Irkutsk 664033, Russia
[2] SASTRA Univ, Ctr Nanotechnol & Adv Biomat CeNTAB, Sch Chem & Biotechnol, Thanjavur 613401, Tamil Nadu, India
来源：
ARKIVOC | 2018年
基金：
俄罗斯科学基金会;
关键词：
Fluorescein; N; N-dimethylamide; pH-independent fluorescence; tagged polymers; GENE; POLY(1-VINYLIMIDAZOLE); BENZOQUINONE; DELIVERY; DESIGN;
D O I：
10.24820/ark.5550190.p010.714
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three new fluorescein based dyes were obtained as reagents for tagging of compounds which contain amine, imidazole or chloroanhydride groups. The proposed substances were tested with three polymers which are promising as gene delivery agents. The new compounds as opposed to derivatives of fluorescein with free 2'-carboxyl group remain fluorescent in acidic media. Such behavior of new tags is useful in study of biological systems, e.g. acidic lysosomes which can capture various substances including gene delivery agents. [GRAPHICS] .
引用
收藏
页码：357 / 372
页数：16
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