Digital microfluidics: a versatile tool for applications in chemistry, biology and medicine

被引：245
作者：
Jebrail, Mais J. [2 ]
Bartsch, Michael S.
Patel, Kamlesh D. [1 ]
机构：
[1] Sandia Natl Labs, Adv Syst Engn & Dev Grp, Livermore, CA 94550 USA
[2] Sandia Natl Labs, Dept Biotechnol & Bioengn, Livermore, CA 94550 USA
来源：
LAB ON A CHIP | 2012年 / 12卷 / 14期
基金：
加拿大自然科学与工程研究理事会; 美国能源部;
关键词：
ON-A-CHIP; ELECTROWETTING-BASED ACTUATION; POLYMERASE-CHAIN-REACTION; DROPLET MICROFLUIDICS; PLURONIC ADDITIVES; SAMPLE PREPARATION; LIQUID DROPLETS; CONTINUOUS-FLOW; PLATFORM; DEVICES;
D O I：
10.1039/c2lc40318h
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Digital microfluidics (DMF) has recently emerged as a popular technology for a wide range of applications. In DMF, nanoliter to microliter droplets containing samples and reagents can be manipulated to carry out a range of discrete fluidic operations simply by applying a series of electrical potentials to an array of patterned electrodes coated with a hydrophobic insulator. DMF is distinct from microchannel-based fluidics as it allows for precise control over multiple reagent phases (liquids and solids) in heterogeneous systems with no need for complex networks of connections, microvalves, or pumps. In this review, we discuss the most recent developments in this technology with particular attention to the potential benefits and outstanding challenges for applications in chemistry, biology, and medicine.
引用
收藏
页码：2452 / 2463
页数：12
相关论文
共 102 条
[1]  
Abdelgawad M, 2008, LAB CHIP, V8, P672, DOI 10.1039/b801516c
[2]   Optimization of device geometry in single-plate digital microfluidics [J].
Abdelgawad, Mohamed ;
Park, Philip ;
Wheeler, Aaron R. .
JOURNAL OF APPLIED PHYSICS, 2009, 105 (09)
[3]   The Digital Revolution: A New Paradigm for Microfluidics [J].
Abdelgawad, Mohamed ;
Wheeler, Aaron R. .
ADVANCED MATERIALS, 2009, 21 (08) :920-925
[4]   Hybrid microfluidics: A digital-to-channel interface for in-line sample processing and chemical separations [J].
Abdelgawad, Mohamed ;
Watson, Michael W. L. ;
Wheeler, Aaron R. .
LAB ON A CHIP, 2009, 9 (08) :1046-1051
[5]  
Arnaud CH, 2011, CHEM ENG NEWS, V89, P13
[6]   A New Angle on Pluronic Additives: Advancing Droplets and Understanding in Digital Microfluidics [J].
Au, Sam H. ;
Kumar, Paresh ;
Wheeler, Aaron R. .
LANGMUIR, 2011, 27 (13) :8586-8594
[7]   Integrated microbioreactor for culture and analysis of bacteria, algae and yeast [J].
Au, Sam H. ;
Shih, Steve C. C. ;
Wheeler, Aaron R. .
BIOMEDICAL MICRODEVICES, 2011, 13 (01) :41-50
[8]   Electrostatic force calculation for an EWOD-actuated droplet [J].
Baird, E. ;
Young, P. ;
Mohseni, K. .
MICROFLUIDICS AND NANOFLUIDICS, 2007, 3 (06) :635-644
[9]   Online Coupling of Digital Microfluidic Devices with Mass Spectrometry Detection Using an Eductor with Electrospray Ionization [J].
Baker, Christopher A. ;
Roper, Michael G. .
ANALYTICAL CHEMISTRY, 2012, 84 (06) :2955-2960
[10]   Digital microfluidics for cell-based assays [J].
Barbulovic-Nad, Irena ;
Yang, Hao ;
Park, Philip S. ;
Wheeler, Aaron R. .
LAB ON A CHIP, 2008, 8 (04) :519-526
12345678910