Another Piece of the Myeloproliferative Neoplasms Puzzle

被引：8

作者：

Levine, Ross L. ^{[1
,2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, Human Oncol & Pathogenesis Program, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, NY 10021 USA

[3] Weill Cornell Med Coll, New York, NY USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2013年 / 369卷 / 25期

关键词：

TYROSINE KINASE JAK2; POLYCYTHEMIA-VERA; ACTIVATING MUTATION; MYELOID METAPLASIA; MYELOFIBROSIS; DISORDERS;

D O I：

10.1056/NEJMe1313643

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myeloproliferative neoplasms are clonal hematopoietic disorders that manifest as expansion of one or more myeloid lineages. The most common myeloproliferative neoplasms are chronic myeloid leukemia (CML), polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Whereas the genetic basis for CML has been known for more than 30 years, the specific genetic events that contribute to the pathogenesis of polycythemia vera, essential thrombocythemia, and primary myelofibrosis remained unknown until 2005. Our first insight into the molecular cause of these disorders came when the somatic JAK2 V617F mutation(1)-(4) was identified in the majority of patients with polycythemia vera and in a subset ...

引用

页码：2451 / 2452

页数：2

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