Oligodendrocytes as providers of growth factors

被引：197
作者：
Du, YZ [1 ]
Dreyfus, CF [1 ]
机构：
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 2002年 / 68卷 / 06期
关键词：
glia; neurotrophins; neuregulins; trophic effects of oligodendrocytes;
D O I：
10.1002/jnr.10245
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Glial cells recently are being appreciated as supporters of brain neurons. This review addresses their role as growth factor providers. While the function of astrocytes in this capacity is known, new data indicate that oligodendrocytes, the myelinating cells of the brain, exhibit similar abilities. Oligodendrocytes provide trophic signals to nearby neurons and synthesize defined growth factors. Expression of growth factors is influenced by neural signals. The review summarizes these roles and their implications in brain function. (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码：647 / 654
页数：8
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