A critical role for the glial-derived neuromodulator D-serine in the age-related deficits of cellular mechanisms of learning and memory

被引：143

作者：

Mothet, J. P. ^{[1
]}

Rouaud, E. ^{[1
]}

Sinet, P. -M. ^{[1
]}

Potier, B. ^{[1
]}

Jouvenceau, A. ^{[1
]}

Dutar, P. ^{[1
]}

Videau, C. ^{[1
]}

Epelbaum, J. ^{[1
]}

Billard, J. -M. ^{[1
]}

机构：

[1] Univ Paris Descartes, Fac Med, UMR 549, INSERM, F-75014 Paris, France

来源：

AGING CELL | 2006年 / 5卷 / 03期

关键词：

aging; astrocyte; glutamate; hippocampus; NMDA receptor; synaptic plasticity;

D O I：

10.1111/j.1474-9726.2006.00216.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Age-associated deficits in learning and memory are closely correlated with impairments of synaptic plasticity. Analysis of N-methyl-D-aspartate receptor (NMDAr)-dependent long-term potentiation (LTP) in CA1 hippocampal slices indicates that the glial-derived neuromodulator D-serine is required for the induction of synaptic plasticity. During aging, the content of D-serine and the expression of its synthesizing enzyme serine racemase are significantly decreased in the hippocampus. Impaired LTP and NMDAr-mediated synaptic potentials in old rats are rescued by exogenous D-serine. These results highlight the critical role of glial cells and presumably astrocytes, through the availability of D-serine, in the deficits of synaptic mechanisms of learning and memory that occur in the course of aging.

引用

页码：267 / 274

页数：8

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