Effectiveness of Vitamin D Supplementation in the Management of Multiple Sclerosis: A Systematic Review

被引:38
作者
Berezowska, Monika [1 ]
Coe, Shelly [1 ]
Dawes, Helen [1 ]
机构
[1] Oxford Brookes Univ, Ctr Movement Occupat & Rehabil Sci, Oxford OX3 0BP, England
关键词
Vitamin D; Multiple Sclerosis; symptom; RELAPSE RISK; DOUBLE-BLIND; PROGRESSION; DISABILITY; TRIAL; DIET; BETA;
D O I
10.3390/ijms20061301
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Objective: to examine the extent of effect vitamin D in Multiple Sclerosis (MS) on pathology and symptoms. Methods: A literature search was performed in November 2018 (CRD42018103615). Eligibility criteria: randomised control trials in English from 2012 to 2018; a clinical diagnosis of MS; interventions containing vitamin D supplementation (vitamin D3 or calcitriol) in disease activity compared to a control/placebo; improvement in: serum 25(OH)D, relapse rates, disability status by Expanded Disability Status Scale (EDSS) scores, cytokine profile, quality of life, mobility, T2 lesion load and new T2 or T1 Gd enhancing lesions, safety and adverse effects. Risk of bias was evaluated. Results: Ten studies were selected. The study size ranged from 40 to 94 people. All studies evaluated the use of vitamin D supplementation (ranging from 10 to 98,000 IU), comparing to a placebo or low dose vitamin D. The duration of the intervention ranged from 12 to 96 weeks. One trial found a significant effect on EDSS score, three demonstrated a significant change in serum cytokines level, one found benefits to current enhancing lesions and three studies evaluating the safety and tolerability of vitamin D reported no serious adverse events. Disease measures improved to a greater extent overall in those with lower baseline serum 25(OH)D levels. Conclusions: As shown in 3 out of 10 studies, improvement in disease measures may be more apparent in those with lower baseline vitamin D levels.
引用
收藏
页数:19
相关论文
共 30 条
[1]   Vitamin D3 administration to MS patients leads to increased serum levels of latency activated peptide (LAP) of TGF-beta [J].
Aivo, Julia ;
Hanninen, Arno ;
Ilonen, Jorma ;
Soilu-Hanninen, Merja .
JOURNAL OF NEUROIMMUNOLOGY, 2015, 280 :12-15
[2]   Short-Term Effect of High-Dose Vitamin D on the Level of Interleukin 10 in Patients with Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial [J].
Ashtari, Fereshteh ;
Toghianifar, Nafiseh ;
Zarkesh-Esfahani, Sayyed Hamid ;
Mansourian, Marjan .
NEUROIMMUNOMODULATION, 2015, 22 (06) :400-404
[3]   Influence of Diet in Multiple Sclerosis: A Systematic Review [J].
Bagur, M. Jose ;
Murcia, M. Antonia ;
Jimenez-Monreal, Antonia M. ;
Tur, Josep A. ;
Bibiloni, M. Mar ;
Alonso, Gonzalo L. ;
Martinez-Tome, Magdalena .
ADVANCES IN NUTRITION, 2017, 8 (03) :463-472
[4]   A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis [J].
Burton, J. M. ;
Kimball, S. ;
Vieth, R. ;
Bar-Or, A. ;
Dosch, H. -M. ;
Cheung, R. ;
Gagne, D. ;
D'Souza, C. ;
Ursell, M. ;
O'Connor, P. .
NEUROLOGY, 2010, 74 (23) :1852-1859
[5]   Vitamin D status and the risk of multiple sclerosis: A systematic review and meta-analysis [J].
Duan, Shurong ;
Lv, Zheng ;
Fan, Xiaoxue ;
Wang, Le ;
Han, Fei ;
Wang, Hong ;
Bi, Sheng .
NEUROSCIENCE LETTERS, 2014, 570 :108-113
[6]   Association of Vitamin D Levels With Multiple Sclerosis Activity and Progression in Patients Receiving Interferon Beta-1b [J].
Fitzgerald, Kathryn C. ;
Munger, Kassandra L. ;
Koechert, Karl ;
Arnason, Barry G. W. ;
Comi, Giancarlo ;
Cook, Stuart ;
Goodin, Douglas S. ;
Filippi, Massimo ;
Hartung, Hans-Peter ;
Jeffery, Douglas R. ;
O'Connor, Paul ;
Suarez, Gustavo ;
Sandbrink, Rupert ;
Kappos, Ludwig ;
Pohl, Christoph ;
Ascherio, Alberto .
JAMA NEUROLOGY, 2015, 72 (12) :1458-1465
[7]   Vitamin D supplementation for patients with multiple sclerosis treated with interferon-beta: a randomized controlled trial assessing the effect on flu-like symptoms and immunomodulatory properties [J].
Golan, Daniel ;
Halhal, Basheer ;
Glass-Marmor, Lea ;
Staun-Ram, Elsebeth ;
Rozenberg, Orit ;
Lavi, Idit ;
Dishon, Sara ;
Barak, Mira ;
Ish-Shalom, Sophia ;
Miller, Ariel .
BMC NEUROLOGY, 2013, 13
[8]  
Harandi AA, 2014, IRAN J NEUROL, V13, P1
[9]   Vitamin D for the management of multiple sclerosis [J].
Jagannath, Vanitha A. ;
Filippini, Graziella ;
Di Pietrantonj, Carlo ;
Asokan, G. V. ;
Robak, Edward W. ;
Whamond, Liz ;
Robinson, Sarah A. .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2018, (09)
[10]   Effect of vitamin D3 supplementation on relapses, disease progression, and measures of function in persons with multiple sclerosis: exploratory outcomes from a double-blind randomised controlled trial [J].
Kampman, Margitta T. ;
Steffensen, Linn H. ;
Mellgren, Svein I. ;
Jorgensen, Lone .
MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (08) :1144-1151