Immune mechanisms in malaria: new insights in vaccine development

被引：150

作者：

Riley, Eleanor M. ^{[1
]}

Stewart, V. Ann ^{[2
]}

机构：

[1] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Immunol & Infect, London WC1, England

[2] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA

来源：

NATURE MEDICINE | 2013年 / 19卷 / 02期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

MEROZOITE SURFACE PROTEIN-1; PLASMODIUM-FALCIPARUM INFECTION; T-CELL RESPONSES; CIRCUMSPOROZOITE PROTEIN; MOZAMBICAN CHILDREN; ACQUIRED-IMMUNITY; SYSTEMS BIOLOGY; LIVER STAGES; IFN-GAMMA; FOLLOW-UP;

D O I：

10.1038/nm.3083

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Early data emerging from the first phase 3 trial of a malaria vaccine are raising hopes that a licensed vaccine will soon be available for use in endemic countries, but given the relatively low efficacy of the vaccine, this needs to be seen as a major step forward on the road to a malaria vaccine rather than as arrival at the final destination. The focus for vaccine developers now moves to the next generation of malaria vaccines, but it is not yet clear what characteristics these new vaccines should have or how they can be evaluated. Here we briefly review the epidemiological and immunological requirements for malaria vaccines and the recent history of malaria vaccine development and then put forward a manifesto for future research in this area. We argue that rational design of more effective malaria vaccines will be accelerated by a better understanding of the immune effector mechanisms involved in parasite regulation, control and elimination.

引用

页码：168 / 178

页数：11

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