DNA methylome alterations in chemical carcinogenesis

被引：27
作者：
Pogribny, Igor P. [1 ]
Beland, Frederick A. [1 ]
机构：
[1] Natl Ctr Toxicol Res, Div Biochem Toxicol, Jefferson, AR 72079 USA
来源：
CANCER LETTERS | 2013年 / 334卷 / 01期
关键词：
Carcinogenesis; DNA methylation; Genotoxic carcinogens; Non-genotoxic carcinogens; GENE-PROMOTER HYPERMETHYLATION; CPG ISLAND HYPERMETHYLATION; LUNG-CANCER; HEPATOCELLULAR-CARCINOMA; METHYLATION PATTERNS; EPIGENETIC CHANGES; COLON-CANCER; CHROMOSOMAL INSTABILITY; CYTOSINE METHYLATION; ABERRANT METHYLATION;
D O I：
10.1016/j.canlet.2012.09.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Carcinogenesis, a complex multifactorial process of the transformation of normal cells into malignant cells, is characterized by many biologically significant and interdependent alterations triggered by the mutational and/or non-mutational (i.e., epigenetic) events. One of these events, specific to all types of cancer, is alterations in DNA methylation. This review summarizes the current knowledge of the role of DNA methylation changes induced by various genotoxic chemicals (carcinogenic agents that interact with DNA) and non-genotoxic carcinogens (chemicals causing tumor by mechanisms other than directly damaging DNA) in the lung, colorectal, liver, and hematologic carcinogenesis. It also emphasizes the potential role for epigenetic changes to serve as markers for carcinogen exposure and carcinogen risk assessment. Published by Elsevier Ireland Ltd.
引用
收藏
页码：39 / 45
页数：7
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