An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes

被引:303
作者
Aniento, F [1 ]
Gu, F [1 ]
Parton, RG [1 ]
Gruenberg, J [1 ]
机构
[1] EUROPEAN MOLEC BIOL LAB,D-69012 HEIDELBERG,GERMANY
关键词
D O I
10.1083/jcb.133.1.29
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In this paper, we show that beta COP is present on endosomes and is required for the formation of vesicles which mediate transport from early to late endosomes. Both the association of beta COP to endosomal membranes as well as transport vesicle formation depend on the lumenal pH. We find that epsilon COP, but not gamma COP, is also associated to endosomes, and that this association is also lumenal pH dependent. Our data, thus, indicate that a subset of COPs is part of the mechanism regulating endosomal membrane transport, and that membrane association of these COPs is controlled by the acidic properties of early endosomes, presumably via a trans-membrane pH sensor.
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收藏
页码:29 / 41
页数:13
相关论文
共 72 条
[1]   A MICROTUBULE-BINDING PROTEIN ASSOCIATED WITH MEMBRANES OF THE GOLGI-APPARATUS [J].
ALLAN, VJ ;
KREIS, TE .
JOURNAL OF CELL BIOLOGY, 1986, 103 (06) :2229-2239
[2]  
ANIENTO F, 1993, J BIOL CHEM, V268, P10463
[3]   CYTOPLASMIC DYNEIN-DEPENDENT VESICULAR TRANSPORT FROM EARLY TO LATE ENDOSOMES [J].
ANIENTO, F ;
EMANS, N ;
GRIFFITHS, G ;
GRUENBERG, J .
JOURNAL OF CELL BIOLOGY, 1993, 123 (06) :1373-1387
[4]   DEFECTIVE ACIDIFICATION OF INTRACELLULAR ORGANELLES IN CYSTIC-FIBROSIS [J].
BARASCH, J ;
KISS, B ;
PRINCE, A ;
SAIMAN, L ;
GRUENERT, D ;
ALAWQATI, Q .
NATURE, 1991, 352 (6330) :70-73
[5]   COPII - A MEMBRANE COAT FORMED BY SEC PROTEINS THAT DRIVE VESICLE BUDDING FROM THE ENDOPLASMIC-RETICULUM [J].
BARLOWE, C ;
ORCI, L ;
YEUNG, T ;
HOSOBUCHI, M ;
HAMAMOTO, S ;
SALAMA, N ;
REXACH, MF ;
RAVAZZOLA, M ;
AMHERDT, M ;
SCHEKMAN, R .
CELL, 1994, 77 (06) :895-907
[6]   MICROTUBULE-DEPENDENT AND MOTOR-DEPENDENT FUSION INVITRO BETWEEN APICAL AND BASOLATERAL ENDOCYTIC VESICLES FROM MDCK CELLS [J].
BOMSEL, M ;
PARTON, R ;
KUZNETSOV, SA ;
SCHROER, TA ;
GRUENBERG, J .
CELL, 1990, 62 (04) :719-731
[7]   BAFILOMYCINS - A CLASS OF INHIBITORS OF MEMBRANE ATPASES FROM MICROORGANISMS, ANIMAL-CELLS, AND PLANT-CELLS [J].
BOWMAN, EJ ;
SIEBERS, A ;
ALTENDORF, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) :7972-7976
[8]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[9]   MULTIPLE GTP-BINDING PROTEINS PARTICIPATE IN CLATHRIN-COATED VESICLE-MEDIATED ENDOCYTOSIS [J].
CARTER, LL ;
REDELMEIER, TE ;
WOOLLENWEBER, LA ;
SCHMID, SL .
JOURNAL OF CELL BIOLOGY, 1993, 120 (01) :37-45
[10]   THE HUMAN KERATINOCYTE 2-DIMENSIONAL PROTEIN DATABASE (UPDATE-1994) - TOWARDS AN INTEGRATED APPROACH TO THE STUDY OF CELL-PROLIFERATION, DIFFERENTIATION AND SKIN-DISEASES [J].
CELIS, JE ;
RASMUSSEN, HH ;
OLSEN, E ;
MADSEN, P ;
LEFFERS, H ;
HONORE, B ;
DEJGAARD, K ;
GROMOV, P ;
VORUM, H ;
VASSILEV, A ;
BASKIN, Y ;
LIU, XD ;
CELIS, A ;
BASSE, B ;
LAURIDSEN, JB ;
RATZ, GP ;
ANDERSEN, AH ;
WALBUM, E ;
KJAERGAARD, I ;
ANDERSEN, I ;
PUYPE, M ;
VANDAMME, J ;
VANDEKERCKHOVE, J .
ELECTROPHORESIS, 1994, 15 (11) :1349-1458