Oxime Cross-Linked Injectable Hydrogels for Catheter Delivery

被引：113

作者：

Grover, Gregory N. ^{[1
]}

Braden, Rebecca L. ^{[1
]}

Christman, Karen L. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 21期

基金：

美国国家卫生研究院;

关键词：

injectable hydrogels; catheters; oxime cross-linking; LEFT-VENTRICULAR FUNCTION; MYOCARDIAL-INFARCTION; CARDIAC-FUNCTION; HEART; INJECTION; ALGINATE; CELLS; ANGIOGENESIS; BIOMATERIALS; EXPANSION;

D O I：

10.1002/adma.201205234

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catheter delivery of therapeutic materials is important for developing minimally invasive treatment approaches. However, the majority of injectable materials gel rapidly upon mixing and/or heating to body temperature. The application of an oxime cross-linked hydrogel system is demonstrated. The system has a broad range of tunable gelation rates, is capable of injection through a catheter, and exhibits rapid gelation upon injection into tissue. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2937 / 2942

页数：6

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