NK cells: a double-edged sword in chronic hepatitis B virus infection

被引：97
作者：
Maini, Mala K. [1 ]
Peppa, Dimitra [1 ]
机构：
[1] UCL, Div Infect & Immun, London WC1E 6JF, England
来源：
FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷
关键词：
NK cells; hepatitis B virus; TRAIL; interferon-gamma; IL-10; CD56(bright); IFN-alfa; liver damage; APOPTOSIS-INDUCING LIGAND; NATURAL-KILLER-CELLS; ADAPTIVE IMMUNE-RESPONSES; T-CELLS; INTRAHEPATIC LYMPHOCYTES; HEPATOCELLULAR-CARCINOMA; VIRAL CLEARANCE; STELLATE CELLS; LIVER-INJURY; MOUSE MODEL;
D O I：
10.3389/fimmu.2013.00057
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
There is natural enrichment of NK cells in the human liver and this intrahepatic predominance underscores their potential importance in the control of infections with hepatotropic viruses such as hepatitis B virus (HBV). The contribution of innate components during chronic HBV infection has been a relatively under-investigated area. However, recent data have highlighted that NK cells are capable of exerting antiviral and immunoregulatory functions whilst also contributing to the pathogenesis of liver injury via death receptor pathways. We will present an overview of current knowledge regarding the complex biology of NK cells in the context of their antiviral versus pathogenic role in chronic hepatitis B as a clinically relevant avenue for further investigation.
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页数：7
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