Resistance to annexin A5 anticoagulant activity: a thrombogenic mechanism for the antiphospholipid syndrome

被引：49
作者：
Rand, J. H. [1 ]
Wu, X. X. [1 ]
Quinn, A. S. [2 ,3 ]
Taatjes, D. J. [2 ,3 ]
机构：
[1] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Pathol, Core Lab Off, Bronx, NY 10467 USA
[2] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA
[3] Univ Vermont, Coll Med, Microscopy Imaging Ctr, Burlington, VT USA
来源：
LUPUS | 2008年 / 17卷 / 10期
基金：
美国国家卫生研究院;
关键词：
anticardiolipin antibodies; antiphospholipid syndrome; Hughes syndrome; lupus anticoagulant; pregnancy; thrombosis;
D O I：
10.1177/0961203308095029
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The phospholipids binding protein, annexin A5 (AnxA5), has potent anticoagulant properties that result from its forming 2-dimensional crystals over phospholipids, blocking the availability of the phospholipids for critical coagulation enzyme reactions. This article reviews the evidence that antiphospholipids antibodies can disrupt this anticoagulant shield and unmask thrombogenic anionic phospholipids, which may thereby contribute to thrombosis in patients with the antiphospholipid syndrome (APS). This mechanism for thrombosis in APS can be monitored with coagulation assays for resistance to anticoagulant activity of AnxA5. Lupus (2008) 17,922-930.
引用
收藏
页码：922 / 930
页数：9
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