Is Statin Therapy Safe and Effective in Patients with Chronic Kidney Disease?

被引：1

作者：

Raman, Venkatesh K. ^{[1
]}

Geladari, Eleni ^{[2
,3
]}

Papademetriou, Vasilios ^{[2
,3
]}

机构：

[1] MedStar Georgetown Univ Hosp, MedStar Heart & Vasc Inst, Washington, DC USA

[2] Vet Affairs Med Ctr, 50 Irving St NW, Washington, DC 20422 USA

[3] Georgetown Univ, Washington, DC USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2017年 / 23卷 / 46期

关键词：

Chronic kidney disease; end-stage renal disease; hemodialysis; statin; cholesterol; lipids; TYPE-2; DIABETES-MELLITUS; CORONARY-HEART-DISEASE; CARDIOVASCULAR EVENTS; LDL CHOLESTEROL; REDUCING LIPIDS; RENAL-FUNCTION; HIGH-RISK; ASSOCIATION; METAANALYSIS; ALBUMINURIA;

D O I：

10.2174/1381612824666180110100103

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic kidney disease (CKD) is associated with dyslipidemia and increased cardiovascular risk. This elevated risk for cardiovascular events exists even in the largest subpopulation with milder stages of CKD, prior to the development of significant reductions in renal excretory function. Statin therapy is a critical component of primary and secondary cardiovascular prevention efforts for at-risk patients. Efficacy in the CKD population, however, has appeared less robust across the spectrum of CKD, particularly in hemodialysis patients. This article will review the current state of knowledge on statin therapy in CKD, effects on renal outcomes, safety in this population and alternative lipid therapies.

引用

页码：7135 / 7140

页数：6

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