Transformation of 8-prenylnaringenin by Absidia coerulea and Beauveria bassiana

被引：27

作者：

Bartmanska, Agnieszka ^{[1
]}

Tronina, Tomasz ^{[1
]}

Huszcza, Ewa ^{[1
]}

机构：

[1] Wroclaw Univ Environm & Life Sci, Dept Chem, PL-50375 Wroclaw, Poland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 20期

关键词：

8-Prenylnaringenin; Glycosidation; Sulfation; Absidia coerulea; Beauveria bassiana; HOPS HUMULUS-LUPULUS; MICROBIAL-METABOLISM; POTENT PHYTOESTROGEN; SULFATED FLAVONOIDS; LEAVES;

D O I：

10.1016/j.bmcl.2012.08.060

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Beauveria bassiana AM278 and Absidia coerulea AM93 converted 8-prenylnaringenin (1) into two glycoside derivatives (7-O-beta-D-glucopyranoside) (2) and 7-O-beta-D-4 '''-O-methylglucopyranoside) (3) in high yields in processes conducted in Saboraud medium. 8-Prenylnaringenin 7-O-beta-D-4 '''-O-methylglucopyranoside (3) is a new compound. 8-Prenylnaringenin-7-sulfate (4) was obtained in transformation of 1 by Absidia coerulea AM93 in a buffer. Formation of conjugated products in this study proceeds in a manner analogous to mammalian systems which indicates the potential use of microbes to mimic mammalian metabolism. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：6451 / 6453

页数：3

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