Applications of poly(ethylene oxide) in controlled release tablet systems: a review

被引：110
作者：
Ma, Lulu [1 ,2 ]
Deng, Li [1 ]
Chen, Jianming [1 ]
机构：
[1] Second Mil Med Univ, Sch Pharm, Dept Pharmaceut, Shanghai, Peoples R China
[2] Bengbu Med Coll, Affiliated Hosp 1, Dept Pharm, Bengbu, Peoples R China
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2014年 / 40卷 / 07期
关键词：
Bioadhesive hydrophilic matrix; commercial product; controlled release tablet; matrix tablet; osmotic pump tablet; PEO; physicochemical properties; DRUG-DELIVERY SYSTEM; NIFEDIPINE CONTROLLED DELIVERY; HYDROPHILIC MATRIX TABLETS; ELEMENTARY OSMOTIC PUMP; IN-VITRO EVALUATION; WATER-SOLUBLE DRUG; POLYETHYLENE OXIDE; PHYSICAL-CHARACTERIZATION; MOLECULAR-WEIGHTS; POLYMER HYDRATION;
D O I：
10.3109/03639045.2013.831438
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
To improve therapeutic effects and compatibility of patients, controlled release tablet systems based on polymers are of great interest for pharmaceutical technologies. Poly(ethylene oxide) (PEO) is a non-ionic linear hydrophilic and uncrosslinked polymer available in a number of molecular weights. It is synthesized by ethylene oxide and has many desirable properties for drug delivery applications. This review article aims to summary the recent developments on physicochemical properties of PEO and focus on the recent efforts and developments on PEO as oral controlled release matrix tablets, bioadhesive hydrophilic matrices and osmotic pump tablets. Commercial products employed PEO were also discussed.
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收藏
页码：845 / 851
页数：7
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