Improvement of dissolution rate of poorly water soluble drugs using a new particle engineering process: Spray freezing into liquid

Biopharmaceutics Classification System (BCS) Class II drugs are classified as having poor water solubility and good permeability across biological membranes. Improving the dissolution should, therefore, increase the bioavailability of this class of drugs. The Spray-Freezing into Liquid (SFL) process has been shown to increase dissolution rates of BCS class II drugs by providing amorphous particles with high surface area and small primary particle size, stabilized using hydrophilic polymers. Modifying the physicochemical properties of the particles is accomplished by selecting the optimum feed system composition. This article reviews the influence of this composition and active pharmaceutical ingredient (API) potency on surface area, surface morphology, crystallinity, and dissolution rates of model API.