Synthesis and study of some 4-aza and 17a-azasteroidal isoxazoles

被引：11

作者：

Gupta, R ^{[1
]}

Pathak, D ^{[1
]}

Jindal, DP ^{[1
]}

机构：

[1] Panjab Univ, Inst Pharmaceut Sci, Chandigarh 160014, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 34卷 / 7-8期

关键词：

azasteroids; isoxazoles; aromatase inhibitors; trilostane; danazol;

D O I：

10.1016/S0223-5234(00)80035-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

4-Aza-5 alpha-androstano[2,3-6]isoxazole 4 and 17a-aza-D-homo-5-androsteno[17, 16-c]isoxazole 7 have been prepared by treating alpha,beta-unsaturated-beta-chloroaldehydes 3 and 6 [1, 2] with hydroxylamine hydrochloride in pyridine. [16,17-d]Isoxazole derivatives 4 and 8 were found to be unstable in most of the organic solvents. beta-Cyanolactam derivatives 5 and 9 have also been prepared in both the series. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

引用

页码：659 / 662

页数：4

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