Silver carbene complexes: An emerging class of anticancer agents

被引：29

作者：

Kankala, Shravankumar ^{[1
]}

Thota, Niranjan ^{[2
]}

Bjorkling, Fredrik ^{[2
]}

Taylor, Myles K. ^{[3
]}

Vadde, Ravinder ^{[1
]}

Balusu, Ramesh ^{[3
,4
]}

机构：

[1] Kakatiya Univ, Dept Chem, Warangal 506009, Telangana, India

[2] Univ Copenhagen, Fac Hlth & Med Sci, Dept Drug Design & Pharmacol, Copenhagen, Denmark

[3] Univ Kansas, Med Ctr, 2006 WHW,Mail Stop 1027,3901 Rainbow Blvd, Kansas City, KS 66160 USA

[4] Univ Kansas, Med Ctr, Dept Internal Med, Div Hematol Malignancies & Cellular Therapeut, Kansas City, KS 66103 USA

来源：

DRUG DEVELOPMENT RESEARCH | 2019年 / 80卷 / 02期

关键词：

antineoplastic; drug design; mechanistic study; mitochondria; silver carbene complexes; N-HETEROCYCLIC CARBENES; MAIN-GROUP ELEMENTS; IN-VITRO; GOLD(III) COMPLEXES; CRYSTAL-STRUCTURES; TRANSITION-METALS; MULTIPLE BONDS; CYTOTOXICITY; LIGANDS; ANTIBACTERIAL;

D O I：

10.1002/ddr.21478

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cancer is a major global health problem with large therapeutic challenges. Although substantial progress has been made in cancer therapy, there still remains a need to develop novel and effective treatment strategies to treat several relapsed and refractory cancers. Recently, there has been growing demand for considering organometallics as antineoplastic agents. This review is focused on a group of organometallics, silver N-heterocyclic carbene complexes (SCCs) and their anticancer efficacy in targeting multiple pathways in various in vitro cancer model systems. However, the precise molecular mechanism of SCCs anticancer properties remains unclear. Here, we discuss the SCCs chemistry, potential molecular targets, possible molecular mechanism of action, and their application in cancer therapies.

引用

页码：188 / 199

页数：12

共 100 条

[1] In vitro cytotoxic activities of new silver and PEPPSI palladium N-heterocyclic carbene complexes derived from benzimidazolium salts [J].