SPECTROPHOTOMETRIC DETERMINATION OF KETOPROFEN AND ITS APPLICATION IN PHARMACEUTICAL ANALYSIS

被引：0
作者：
Kormosh, Zholt [1 ]
Hunka, Iryna [1 ]
Basel, Yaroslav [2 ]
机构：
[1] Volyn Natl Univ, Dept Analyt Chem, Lutsk, Ukraine
[2] Safarik Univ, Dept Analyt Chem, Kosice, Slovakia
来源：
ACTA POLONIAE PHARMACEUTICA | 2009年 / 66卷 / 01期
关键词：
ketoprofen determination; Astra Phloxin FF; spectrophotometry; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LIQUID-CHROMATOGRAPHY; HPLC; SAMPLES; PLASMA;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A new simple rapid and sensitive spectrophotometric method has been developed for the determination of ketoprofen in pharmaceutical preparations. The method is based on the reaction of ketoprofen with an analytical reagent - Astra Phloxin FF - at pH 8.0 - 10.8 and followed by the extraction of formed ion associate in toluene with spectrophotometric detection (it has an absorption maximum at 563 nun, epsilon = 7.6 x 10(4) Lxmol(-1)xcm(-1)). The calibration plot was linear from 0.8 - 16.0 mu gxmL(-1) of ketoprofen, and the detection limit was 0.037 mu gxmL(-1).
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页码：3 / 9
页数：7
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