Angle-multiplexed all-dielectric metasurfaces for broadband molecular fingerprint retrieval

被引:444
作者
Leitis, Aleksandrs [1 ]
Tittl, Andreas [1 ]
Liu, Mingkai [2 ]
Lee, Bang Hyun [3 ]
Gu, Man Bock [3 ]
Kivshar, Yuri S. [2 ]
Altug, Hatice [1 ]
机构
[1] Ecole Polytech Fed Lausanne, Inst Bioengn, CH-1015 Lausanne, Switzerland
[2] Australian Natl Univ, Nonlinear Phys Ctr, Canberra, ACT 2601, Australia
[3] Korea Univ, Dept Biotechnol, Coll Life Sci & Biotechnol, Seoul, South Korea
基金
欧洲研究理事会; 欧盟地平线“2020”;
关键词
LABEL-FREE; INFRARED-SPECTROSCOPY; OPTICAL BIOSENSORS; PROTEIN ODAM; ABSORPTION; SENSORS;
D O I
10.1126/sciadv.aaw2871
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Infrared spectroscopy resolves the structure of molecules by detecting their characteristic vibrational fingerprints. Subwavelength light confinement and nanophotonic enhancement have extended the scope of this technique for monolayer studies. However, current approaches still require complex spectroscopic equipment or tunable light sources. Here, we introduce a novel metasurface-based method for detecting molecular absorption fingerprints over a broad spectrum, which combines the device-level simplicity of state-of-the-art angle-scanning refractometric sensors with the chemical specificity of infrared spectroscopy. Specifically, we develop germanium-based high-Q metasurfaces capable of delivering a multitude of spectrally selective and surface-sensitive resonances between 1100 and 1800 cm(-1). We use this approach to detect distinct absorption signatures of different interacting analytes including proteins, aptamers, and polylysine. In combination with broadband incoherent illumination and detection, our method correlates the total reflectance signal at each incidence angle with the strength of the molecular absorption, enabling spectrometer-less operation in a compact angle-scanning configuration ideally suited for field-deployable applications.
引用
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页数:8
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