PIP3, PIP2, and cell movement - Similar messages, different meanings?

被引：170

作者：

Insall, RH ^{[1
]}

Weiner, OD

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

[2] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

DEVELOPMENTAL CELL | 2001年 / 1卷 / 06期

关键词：

D O I：

10.1016/S1534-5807(01)00086-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The inositol lipids PI(4,5)P-2 and PI(3,4,5)P-3 are important regulators of actin polymerization, but their different temporal and spatial dynamics suggest that they perform separate roles. PI(3,4,5)P-3 seems to act as an instructive second messenger, inducing local actin polymerization. PI(4,5)P-2 appears to be present at too high a concentration and homogenous a distribution to fulfil a similar role. Instead, we suggest that PI(4,5)P-2 acts permissively, restricting new actin polymerization to the region of the plasma membrane.

引用

页码：743 / 747

页数：5

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