How Reversed-Phase Liquid Chromatography Works

被引：0
|
作者：
Schure, Mark R. [1 ]
Rafferty, Jake L. [2 ,3 ,4 ]
Zhang, Ling [2 ,3 ]
Siepmann, J. Ilja [2 ,3 ,4 ,5 ]
机构：
[1] Kroungold Analyt Inc, Superon & Theoret Separat Sci Lab, Blue Bell, PA USA
[2] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Chem Theory Ctr, Minneapolis, MN USA
[4] North Hennepin Community Coll, Dept Chem, Brooklyn Pk, MN USA
[5] Univ Minnesota, Dept Chem Engn & Mat Sci, Minneapolis, MN 55455 USA
来源：
LC GC NORTH AMERICA | 2013年 / 31卷 / 08期
基金：
美国国家科学基金会;
关键词：
MOLECULAR SIMULATION; RETENTION MECHANISM; STATIONARY-PHASE; CHAIN-LENGTH; WATER; ADSORPTION; CONFORMATION; COVERAGE;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The keys to understanding reversed-phase liquid chromatography (LC) are provided at the molecular mechanism level as determined by high accuracy molecular simulation. The essential features of C-18 stationary-phase chains in contact with methanol-water and acetonitrile-water mixtures are discussed in the context of bonded-chain geometry, spatial distribution of alkane and alcohol solutes, retention mechanism, and retention thermodynamics. This tutorial is intended to be applicable to a wide audience ranging from occasional users of liquid chromatography to separation scientists.
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页码：630 / 637
页数：8
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