Eco-Friendly Electrochemical Biosensor based on Sodium Carboxymethyl Cellulose/Reduced Graphene Oxide Composite

Reduced graphene oxide (GO) and carboxymethyl cellulose sodium (CMC) composite film was prepared by a simple solution blending method. The obtained composite film was used to modify glassy carbon electrode (GCE) to detect Vitamin B-6 (VB6) with electrochemical measurements. Morphologies and stucture of the composite were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR) and electron paramagnetic resonance (EPR). The electrochemistry performances of the GCE modified by GO/CMC composite were investigated by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The results revealed that CMC and GO were able to form a homogeneous mixture, and the modified GCE presented extremely strong sensitivity towards VB6 such as high detection sensitivity, low detection limit, small Ret value, certain stability and excellent reversibility. The good performance might be attributed to high electrical conductivity and large surface-to-volume ratio of GO which could accelerate electron transfer between the surface of GCE and VB6. The test results showed that GO/CMC composite was a novel electrochemical biosensor for the detection of VB6.