MeCP2: Making sense of missense in Rett syndrome

被引：6

作者：

Banerjee, Abhishek ^{[1
]}

Romero-Lorenzo, Esmeralda ^{[1
]}

Sur, Mriganka ^{[1
]}

机构：

[1] MIT, Dept Brain & Cognit Sci, Picower Inst Learning & Memory, Cambridge, MA 02139 USA

来源：

CELL RESEARCH | 2013年 / 23卷 / 11期

关键词：

PHOSPHORYLATION; NPAS4;

D O I：

10.1038/cr.2013.109

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fine scale genomic regulation is critical for maintaining genomic integrity and is often disrupted in neurodevelopmental disorders. An intriguing new study reveals the intricate biochemical complexity of de novo post-translational modifications of MeCP2, including activity-dependent protein-protein interactions that 'bridge' the nuclear receptor co-repressor (NCoR) complex to chromatin and lead to alterations in gene expression that characterize Rett syndrome.

引用

页码：1244 / 1246

页数：3

共 10 条

[1]

Banerjee Abhishek, 2012, Front Psychiatry, V3, P34, DOI 10.3389/fpsyt.2012.00034

[2] MeCP2, a key contributor to neurological disease, activates and represses transcription [J].

Chahrour, Maria ;

Jung, Sung Yun ;

Shaw, Chad ;

Zhou, Xiaobo ;

Wong, Stephen T. C. ;

Qin, Jun ;

Zoghbi, Huda Y. .

SCIENCE, 2008, 320 (5880) :1224-1229

[3] The story of Rett syndrome: From clinic to neurobiology [J].

Chahrour, Maria ;

Zoghbi, Huda Y. .

NEURON, 2007, 56 (03) :422-437

[4] Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function [J].

Cohen, Sonia ;

Gabel, Harrison W. ;

Hemberg, Martin ;

Hutchinson, Ashley N. ;

Sadacca, L. Amanda ;

Ebert, Daniel H. ;

Harmin, David A. ;

Greenberg, Rachel S. ;

Verdine, Vanessa K. ;

Zhou, Zhaolan ;

Wetsel, William C. ;

West, Anne E. ;

Greenberg, Michael E. .

NEURON, 2011, 72 (01) :72-85

[5] Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR [J].

Ebert, Daniel H. ;

Gabel, Harrison W. ;

Robinson, Nathaniel D. ;

Kastan, Nathaniel R. ;

Hu, Linda S. ;

Cohen, Sonia ;

Navarro, Adrija J. ;

Lyst, Matthew J. ;

Ekiert, Robert ;

Bird, Adrian P. ;

Greenberg, Michael E. .

NATURE, 2013, 499 (7458) :341-U116

[6] The Role of MeCP2 in the Brain [J].

Guy, Jacky ;

Cheval, Helene ;

Selfridge, Jim ;

Bird, Adrian .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27, 2011, 27 :631-652

[7] Activity-dependent regulation of inhibitory synapse development by Npas4 [J].

Lin, Yingxi ;

Bloodgood, Brenda L. ;

Hauser, Jessica L. ;

Lapan, Ariya D. ;

Koon, Alex C. ;

Kim, Tae-Kyung ;

Hu, Linda S. ;

Malik, Athar N. ;

Greenberg, Michael E. .

NATURE, 2008, 455 (7217) :1198-U23

[8] Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor [J].

Lyst, Matthew J. ;

Ekiert, Robert ;

Ebert, Daniel H. ;

Merusi, Cara ;

Nowak, Jakub ;

Selfridge, Jim ;

Guy, Jacky ;

Kastan, Nathaniel R. ;

Robinson, Nathaniel D. ;

Alves, Flavia de Lima ;

Rappsilber, Juri ;

Greenberg, Michael E. ;

Bird, Adrian .

NATURE NEUROSCIENCE, 2013, 16 (07) :898-U268

[9] Experience-dependent expression of NPAS4 regulates plasticity in adult visual cortex [J].

Maya-Vetencourt, Jose Fernando ;

Tiraboschi, Ettore ;

Greco, Dario ;

Restani, Laura ;

Cerri, Chiara ;

Auvinen, Petri ;

Maffei, Lamberto ;

Castren, Eero .

JOURNAL OF PHYSIOLOGY-LONDON, 2012, 590 (19) :4777-4787

[10] Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice [J].

Tropea, Daniela ;

Giacometti, Emanuela ;

Wilson, Nathan R. ;

Beard, Caroline ;

McCurry, Cortina ;

Fu, Dong Dong ;

Flannery, Ruth ;

Jaenisch, Rudolf ;

Sur, Mriganka .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (06) :2029-2034

← 1 →