共 21 条
Prediction of buried helices in multispan alpha helical membrane proteins
被引:12
作者:

Adamian, L
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Bioengn, Chicago, IL 60612 USA Univ Illinois, Dept Bioengn, Chicago, IL 60612 USA

Liang, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Bioengn, Chicago, IL 60612 USA Univ Illinois, Dept Bioengn, Chicago, IL 60612 USA
机构:
[1] Univ Illinois, Dept Bioengn, Chicago, IL 60612 USA
关键词:
membrane protein;
transmembrane helix;
entropy;
lipophilicity;
TMLIP;
D O I:
10.1002/prot.20874
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Analysis of a database of structures of membrane proteins shows that membrane proteins composed of 10 or more transmembrane (TM) helices often contain buried helices that are inaccessible to phospholipids. We introduce a method for identifying TM helices that are least phospholipid accessible and for prediction of fully buried TM helices in membrane proteins from sequence information alone. Our method is based on the calculation of residue lipophilicity and evolutionary conservation. Given that the number of buried helices in a membrane protein is known, our method achieves an accuracy of 78% and a Matthew's correlation coefficient of 0.68.
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页码:1 / 5
页数:5
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