EMT and Cancer: More Than Meets the Eye

被引：231

作者：

Derynck, Rik ^{[1
,2
]}

Weinberg, Robert A. ^{[3
,4
]}

机构：

[1] Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA

[3] MIT, Whitehead Inst Biomed Res, Ludwig Ctr Mol Oncol, Cambridge, MA 02142 USA

[4] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02142 USA

来源：

DEVELOPMENTAL CELL | 2019年 / 49卷 / 03期

基金：

美国国家卫生研究院;

关键词：

MESENCHYMAL TRANSITION;

D O I：

10.1016/j.devcel.2019.04.026

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epithelial cells acquire mesenchymal characteristics during development, wound healing and inflammation, and in cancer and fibrosis. With increasing appreciation of different roles of epithelial-mesenchymal transition (EMT), we address the question of how to define and recognize EMT processes and discuss their properties in cancer progression.

引用

页码：313 / 316

页数：4

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