ZMYND8 expression combined with pN and pM classification as a novel prognostic prediction model for colorectal cancer: Based on TCGA and GEO database analysis

被引：14
作者：
Chen, Jiewei [1 ,2 ]
He, Qingmei [2 ]
Wu, Peishan [3 ]
Fu, Jianchang [1 ,2 ]
Xiao, Yongbo [1 ,2 ]
Chen, Keming [1 ,2 ]
Xie, Dan [1 ,2 ]
Zhang, Xinke [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Canc Ctr, Dept Pathol, 651 Dong Feng Rd East, Guangzhou 510060, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangdong Esophageal Canc Inst,Canc Ctr, Guangzhou, Guangdong, Peoples R China
[3] Shantou Univ, Affiliated Hosp 2, Med Coll, Pathol, Shantou, Guangdong, Peoples R China
来源：
CANCER BIOMARKERS | 2020年 / 28卷 / 02期
基金：
中国国家自然科学基金;
关键词：
ZMYND8; prognosis; C-index; colorectal cancer; DEMETHYLASE KDM5A; HISTONE; RECOGNITION; SUPPRESSION; PROTEIN; TARGET; GENES; NURD;
D O I：
10.3233/CBM-191261
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: Zinc finger MYND (Myeloid, Nervy and DEAF-1)-type containing 8 (ZMYND8) is closely correlated with tumor proliferation and invasiveness. However, its prognostic value has not been estimated in colorectal cancer (CRC). OBJECTIVE: We aimed to elucidate the prognostic significance of ZMYND8 expression and the pN and pM classification supplemented by its expression in CRCs. METHODS: The candidate gene ZMYND8 is identified by TCGA database and GEO database, and then we retrospectively evaluated the status and prognostic significance of ZMYND8 expression of 174 patients with CRC. RESULTS: Online data showed high expression of ZMYND8 is closely correlated with worse overall survival. Our study revealed high expression of ZMYND8 in CRC patients was significantly associated with worse overall and disease-free survival (P < 0.05), and was an independently adverse prognostic factor for overall survival (P < 0.001) and disease-free survival (P = 0.001) by univariate and multivariate analysis. C-index to combined prognostic model containing the pN, pM classification supplemented by the status of ZMYND8 expression showed improved predictive ability comparing with the pN and pM classification model (C-index of 0.597 vs. 0.545, respectively). CONCLUSION: The combined prognostic model could improve the ability to determine the clinical outcome of patients with CRC.
引用
收藏
页码：201 / 211
页数：11
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