Constitutively active G protein-coupled receptors: Potential mechanisms of receptor activation

被引：88

作者：

Scheer, A ^{[1
]}

Cotecchia, S ^{[1
]}

机构：

[1] UNIV LAUSANNE,INST PHARMACOL & TOXICOL,CH-1005 LAUSANNE,SWITZERLAND

来源：

JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH | 1997年 / 17卷 / 1-3期

关键词：

D O I：

10.3109/10799899709036594

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutations of G protein-coupled receptors can increase their constitutive (agonist-independent) activity. Some of these mutations have been artificially introduced by site-directed mutagenesis, others occur spontaneously in human diseases. The analysis of the constitutively active G protein-coupled receptors has provided important informations about the molecular mechanisms underlying receptor activation and drug action.

引用

页码：57 / 73

页数：17

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