Double nucleophilic attack on isocyanide carbon: a synthetic strategy for 7-aza-tetrahydroindoles

被引：24

作者：

Li, Yifei ^{[1
]}

Xu, Xianxiu ^{[1
]}

Xia, Chunyu ^{[1
]}

Zhang, Lingjuan ^{[1
]}

Pan, Ling ^{[1
]}

Liu, Qun ^{[1
]}

机构：

[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 100期

关键词：

DERIVATIVES; DOMINO; ANNULATION; ALKYNES;

D O I：

10.1039/c2cc35896d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and efficient route for the synthesis of 7-aza-tetrahydroindoles from N-aryl/alkyl-alkenoylacetamides and ethyl isocyanoacetate is described. A mechanism, involving a stepwise [3+2] cycloaddition-intramolecular aza-Michael addition cascade, is proposed that explains the origin of the double nucleophilic attack on the isocyanide carbon atom.

引用

页码：12228 / 12230

页数：3

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