Evaluation of Neoadjuvant Chemotherapy Response in Women with Locally Advanced Breast Cancer Using Ultrasound Elastography

被引：88

作者：

Falou, Omar ^{[1
,2
,3
,4
]}

Sadeghi-Naini, Ali ^{[1
,2
,3
,4
]}

Prematilake, Sameera ^{[1
,2
]}

Sofroni, Ervis ^{[1
,2
]}

Papanicolau, Naum ^{[2
,3
]}

Iradji, Sara ^{[1
,2
]}

Jahedmotlagh, Zahra ^{[1
,2
]}

Lemon-Wong, Sharon ^{[5
]}

Pignol, Jean-Philippe ^{[1
,2
,3
,4
]}

Rakovitch, Eileen ^{[1
,2
,3
,4
]}

Zubovits, Judit ^{[6
]}

Spayne, Jacqueline ^{[1
]}

Dent, Rebecca ^{[7
]}

Trudeau, Maureen ^{[7
]}

Boileau, Jean Francois ^{[8
]}

Wright, Frances C. ^{[8
]}

Yaffe, Martin J. ^{[2
,3
]}

Czarnota, Gregory J. ^{[1
,2
,3
,4
]}

机构：

[1] Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Toronto, ON M4N 3M5, Canada

[2] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[3] Univ Toronto, Fac Med, Dept Med Biophys, Toronto, ON, Canada

[4] Univ Toronto, Fac Med, Dept Radiat Oncol, Toronto, ON, Canada

[5] Sunnybrook Hlth Sci Ctr, Odette Canc Ctr, Dept Nursing, Toronto, ON M4N 3M5, Canada

[6] Sunnybrook Hlth Sci Ctr, Dept Pathol, Toronto, ON M4N 3M5, Canada

[7] Sunnybrook Hlth Sci Ctr, Dept Med Oncol, Toronto, ON M4N 3M5, Canada

[8] Sunnybrook Hlth Sci Ctr, Div Surg Oncol, Toronto, ON M4N 3M5, Canada

来源：

TRANSLATIONAL ONCOLOGY | 2013年 / 6卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

DIFFUSE OPTICAL SPECTROSCOPY; DEATH IN-VITRO; VIVO; LESIONS; ELASTICITY; MALIGNANCY; CARCINOMA; PROSTATE; ABLATION; MASSES;

D O I：

10.1593/tlo.12412

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PURPOSE: Ultrasound elastography is a new imaging technique that can be used to assess tissue stiffness. The aim of this study was to investigate the potential of ultrasound elastography for monitoring treatment response of locally advanced breast cancer patients undergoing neoadjuvant therapy. METHODS: Fifteen women receiving neoadjuvant chemotherapy had the affected breast scanned before, 1, 4, and 8 weeks following therapy initiation, and then before surgery. Changes in elastographic parameters related to tissue biomechanical properties were then determined and compared to clinical and pathologic tumor response after mastectomy. RESULTS: Patients who responded to therapy demonstrated a significant decrease (P < .05) in strain ratios and strain differences 4 weeks after treatment initiation compared to non-responding patients. Mean strain ratio and mean strain difference for responders was 81 +/- 3% and 1 +/- 17% for static regions of interest (ROIs) and 81 +/- 3% and 6 +/- 18% for dynamic ROIs, respectively. In contrast, these parameters were 102 +/- 2%, 110 +/- 17%, 101 +/- 4%, and 109 +/- 30% for non-responding patients, respectively. Strain ratio using static ROIs was found to be the best predictor of treatment response, with 100% sensitivity and 100% specificity obtained 4 weeks after starting treatment. CONCLUSIONS: These results suggest that ultrasound elastography can be potentially used as an early predictor of tumor therapy response in breast cancer patients.

引用

页码：17 / 24

页数：8

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