Headache and Epilepsy

被引：28

作者：

Bauer, P. R. ^{[1
]}

Carpay, J. A. ^{[2
]}

Terwindt, G. M. ^{[2
]}

Sander, J. W. ^{[1
,3
,4
]}

Thijs, R. J. ^{[1
,2
]}

Haan, J. ^{[2
,5
]}

Visser, G. H. ^{[1
]}

机构：

[1] Netherlands Fdn, SEIN Epilepsy Inst, NL-2130 AM Hoofddorp, Netherlands

[2] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands

[3] NIHR Univ Coll London Hosp Biomed Res Ctr, UCL Inst Neurol, London WC1N 3BG, England

[4] Epilepsy Soc, Gerrards Cross SL9 0RJ, England

[5] Rijnland Hosp Leiderdorp, Dept Neurol, NL-2350 CC Leiderdorp, Netherlands

来源：

CURRENT PAIN AND HEADACHE REPORTS | 2013年 / 17卷 / 08期

关键词：

Headache; Migraine; Epilepsy; Post-ictal headache; Peri-ictal headache; Migralepsy; Ictal headache; Cortical excitability; Familial hemiplegic migraine; Cortical spreading depression; Cortical spreading depolarisation; CORTICAL SPREADING DEPRESSION; GENOME-WIDE ASSOCIATION; NEUROLOGICAL DISORDERS; PAROXYSMAL DYSKINESIA; EPILEPTIFORM ACTIVITY; COMORBIDITY PROFILES; GENETIC ASSOCIATION; CHRONIC MIGRAINE; EPISODIC ATAXIA; RECEPTOR;

D O I：

10.1007/s11916-013-0351-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Headache and epilepsy often co-occur. Epidemiologic studies conducted in the past few years reinforce the notion of a bi-directional association between migraine and epilepsy. Data on an association between headache (in general) and epilepsy, however, are less clear. Peri-ictal headache often presents with migraine-like symptoms and can be severe. A correct diagnosis and management are paramount. It was demonstrated that cortical hyperexcitability may underlie both epilepsy and migraine. A recent study linked spreading depolarisation, the supposed underlying pathophysiological mechanism of migraine with aura, to epilepsy. Although this study was carried out in patients who had suffered a subarachnoid haemorrhage, the finding may shed light on pathophysiological mechanisms common to epilepsy and migraine.

引用

页数：9

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