The efficacy of antioxidants in functional recovery of spinal cord injured rats: an experimental study

被引：14
作者：
Robert, Asirvatham Alwin [1 ]
Zamzami, Marwan [2 ]
Sam, Asirvatham Edwin [3 ]
Al Jadid, Maher [4 ]
Al Mubarak, Sultan [5 ]
机构：
[1] Sultan Bin Abdulaziz Humanitarian City, Res Ctr, Riyadh 11536, Saudi Arabia
[2] Sultan Bin Abdulaziz Humanitarian City, Med Affairs, Riyadh 11536, Saudi Arabia
[3] Voluntary Hlth Serv, Chennai, Tamil Nadu, India
[4] Riyadh Mil Hosp, Dept Neurosci, Rehabil Med Div, Riyadh, Saudi Arabia
[5] King Faisal Specialist Hosp & Res Ctr, Res Ctr, Riyadh 11211, Saudi Arabia
来源：
NEUROLOGICAL SCIENCES | 2012年 / 33卷 / 04期
关键词：
Spinal cord injury; Functional recovery; Antioxidant; Alpha-tocopherol; Reparative effects; Ascorbic acid; ALPHA-TOCOPHEROL; ASCORBIC-ACID; BODY-WEIGHT; VITAMIN-E; MICE; REGENERATION; ISCHEMIA; MOTOR; AXONS;
D O I：
10.1007/s10072-011-0829-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A total of 30 female Sprague-Dawley rats (180-220 g) subjected to spinal cord injury (SCI) were divided into three groups of ten rats each. Group 1 served as control (SCI + Saline), Group 2 received daily dose of ascorbic acid 2,000 mg/kg body weight and group 3 rats received alpha tocopherol daily with the dose of 2,000 mg/kg body weight for 14 days. The Spontaneous coordinate activity (SCA), Basso, Beattie, and Bresnahan (BBB) and Tarlov locomotor scores were used to assess functional recovery of SCI rats. Compared to group 1, group 2 showed statistically insignificant improvement in the SCA, BBB and Tarlov scores at the end of the study. Compared to group 1, group 3 showed statistically significant improvement in the SCA (P < 0.001), BBB (P < 0.001) and Tarlov (P < 0.01) scores at the end of the study. In conclusion, the administration of alpha-tocopherol enhances the reparative effects against SCI and it is more effective than ascorbic acid.
引用
收藏
页码：785 / 791
页数：7
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