The efficacy of antioxidants in functional recovery of spinal cord injured rats: an experimental study

被引：14
作者：
Robert, Asirvatham Alwin [1 ]
Zamzami, Marwan [2 ]
Sam, Asirvatham Edwin [3 ]
Al Jadid, Maher [4 ]
Al Mubarak, Sultan [5 ]
机构：
[1] Sultan Bin Abdulaziz Humanitarian City, Res Ctr, Riyadh 11536, Saudi Arabia
[2] Sultan Bin Abdulaziz Humanitarian City, Med Affairs, Riyadh 11536, Saudi Arabia
[3] Voluntary Hlth Serv, Chennai, Tamil Nadu, India
[4] Riyadh Mil Hosp, Dept Neurosci, Rehabil Med Div, Riyadh, Saudi Arabia
[5] King Faisal Specialist Hosp & Res Ctr, Res Ctr, Riyadh 11211, Saudi Arabia
来源：
NEUROLOGICAL SCIENCES | 2012年 / 33卷 / 04期
关键词：
Spinal cord injury; Functional recovery; Antioxidant; Alpha-tocopherol; Reparative effects; Ascorbic acid; ALPHA-TOCOPHEROL; ASCORBIC-ACID; BODY-WEIGHT; VITAMIN-E; MICE; REGENERATION; ISCHEMIA; MOTOR; AXONS;
D O I：
10.1007/s10072-011-0829-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A total of 30 female Sprague-Dawley rats (180-220 g) subjected to spinal cord injury (SCI) were divided into three groups of ten rats each. Group 1 served as control (SCI + Saline), Group 2 received daily dose of ascorbic acid 2,000 mg/kg body weight and group 3 rats received alpha tocopherol daily with the dose of 2,000 mg/kg body weight for 14 days. The Spontaneous coordinate activity (SCA), Basso, Beattie, and Bresnahan (BBB) and Tarlov locomotor scores were used to assess functional recovery of SCI rats. Compared to group 1, group 2 showed statistically insignificant improvement in the SCA, BBB and Tarlov scores at the end of the study. Compared to group 1, group 3 showed statistically significant improvement in the SCA (P < 0.001), BBB (P < 0.001) and Tarlov (P < 0.01) scores at the end of the study. In conclusion, the administration of alpha-tocopherol enhances the reparative effects against SCI and it is more effective than ascorbic acid.
引用
收藏
页码：785 / 791
页数：7
相关论文
共 50 条
  • [21] Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats
    Qiuju Yuan
    Huanxing Su
    Kin Chiu
    Wutian Wu
    Zhi-Xiu Lin
    Neuroscience Bulletin, 2013, 29 : 509 - 516
  • [22] Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats
    Yuan, Qiuju
    Su, Huanxing
    Chiu, Kin
    Wu, Wutian
    Lin, Zhi-Xiu
    NEUROSCIENCE BULLETIN, 2013, 29 (04) : 509 - 516
  • [23] Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats
    Qiuju Yuan
    Huanxing Su
    Kin Chiu
    Wutian Wu
    Zhi-Xiu Lin
    NeuroscienceBulletin, 2013, 29 (04) : 509 - 516
  • [24] Adaptive changes in the injured spinal cord and their role in promoting functional recovery
    Fouad, Karim
    Tse, Arthur
    NEUROLOGICAL RESEARCH, 2008, 30 (01) : 17 - 27
  • [25] Self-assembling peptide gels promote angiogenesis and functional recovery after spinal cord injury in rats
    Hong, Jin Young
    Kim, Su Hee
    Seo, Yoojin
    Jeon, Jooik
    Davaa, Ganchimeg
    Hyun, Jung Keun
    Kim, Soo Hyun
    JOURNAL OF TISSUE ENGINEERING, 2022, 13
  • [26] Rapid functional recovery after spinal cord injury in young rats
    Brown, KM
    Wolfe, BB
    Wrathall, JR
    JOURNAL OF NEUROTRAUMA, 2005, 22 (05) : 559 - 574
  • [27] Numbers of Axons in Spared Neural Tissue Bridges But Not Their Widths or Areas Correlate With Functional Recovery in Spinal Cord-Injured Rats
    Rink, Svenja
    Pavlov, Stoyan
    Woehler, Aliona
    Bendella, Habib
    Manthou, Marilena
    Papamitsou, Theodora
    Dunlop, Sarah A.
    Angelov, Doychin N.
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2020, 79 (11) : 1203 - 1217
  • [28] Protective effects of tadalafil on experimental spinal cord injury in rats
    Serarslan, Yurdal
    Yonden, Zafer
    Ozgiray, Erkin
    Oktar, Sueleyman
    Guven, Esref Oguz
    Sogut, Sadik
    Yilmaz, Nebi
    Yurtseven, Taskin
    JOURNAL OF CLINICAL NEUROSCIENCE, 2010, 17 (03) : 349 - 352
  • [29] Functional recovery after experimental spinal cord compression and whole body vibration therapy requires a balanced revascularization of the injured site
    Manthou, M.
    Nohroudi, K.
    Moscarino, S.
    Rehberg, F.
    Stein, G.
    Jansen, R.
    Abdulla, D.
    Jaminet, P.
    Semler, O.
    Schoenau, E.
    Angelov, D. N.
    RESTORATIVE NEUROLOGY AND NEUROSCIENCE, 2015, 33 (02) : 233 - 249
  • [30] Cholinergic Receptor Alterations in the Brain Stem of Spinal Cord Injured Rats
    Romeo, Chinthu
    Raveendran, Anju Thoppil
    Sobha, Nandhu Mohan
    Paulose, Cheramadathukuzhiyil Scaria
    NEUROCHEMICAL RESEARCH, 2013, 38 (02) : 389 - 397
12345